FBXW2

FBXW2
Identifiers
Aliases	FBXW2, FBW2, Fwd2, Md6, F-box and WD repeat domain containing 2
External IDs	OMIM: 609071; MGI: 1353435; HomoloGene: 8131; GeneCards: FBXW2; OMA:FBXW2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q33.2 Start 120,751,978 bp End 120,793,416 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 B Start 34,694,526 bp End 34,716,323 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell mucosa of sigmoid colon vulva trabecular bone skin of hip skin of thigh lower lobe of lung caput epididymis human penis germinal epithelium Top expressed in dentate gyrus of hippocampal formation granule cell muscle of thigh superior frontal gyrus lumbar spinal ganglion endocardial cushion lip thymus ventricular zone blood neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity Cellular component cytosol Biological process proteolysis protein polyubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26190 30050 Ensembl ENSG00000119402 ENSMUSG00000035949 UniProt Q9UKT8 Q4VXH1 Q60584 RefSeq (mRNA) NM_012164 NM_001375888 NM_001375889 NM_001375890 NM_001164768 NM_001164769 NM_001164770 NM_001164772 NM_013890 NM_001379115 NM_001379116 NM_001379117 NM_001379118 RefSeq (protein) NP_036296 NP_001362817 NP_001362818 NP_001362819 n/a Location (UCSC) Chr 9: 120.75 – 120.79 Mb Chr 2: 34.69 – 34.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the FBXW2 gene.

Function

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.

Interactions

FBXW2 has been shown to interact with SKP1A.

Further reading

• Patton EE, Willems AR, Tyers M (1998). "Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis". Trends Genet. 14 (6): 236–43. doi:10.1016/S0168-9525(98)01473-5. PMID 9635407.
• Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
• Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426 (6962): 87–91. doi:10.1038/nature02082. PMID 14603323.
• Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. doi:10.1073/pnas.0307700101. PMC 384762. PMID 15070733.
• Yang CS, Yu C, Chuang HC, Chang CW, Chang GD, Yao TP, Chen H (2005). "FBW2 targets GCMa to the ubiquitin-proteasome degradation system". J. Biol. Chem. 280 (11): 10083–90. doi:10.1074/jbc.M413986200. PMID 15640526.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.