RARRES1

RARRES1
Identifiers
Aliases	RARRES1, LXNL, TIG1, PERG-1, retinoic acid receptor responder 1
External IDs	OMIM: 605090; MGI: 1924461; HomoloGene: 2166; GeneCards: RARRES1; OMA:RARRES1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	158,732,489 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	67,422,856 bp
RNA expression pattern
	Top expressed in
	pericardium; ; palpebral conjunctiva; ; olfactory zone of nasal mucosa; ; left uterine tube; ; germinal epithelium; ; nasal epithelium; ; gastric mucosa; ; urethra; ; parietal pleura; ; tail of epididymis;
	Top expressed in
	lip; ; skin of external ear; ; skin of abdomen; ; lumbar spinal ganglion; ; left lobe of liver; ; skin of back; ; seminal vesicula; ; embryo; ; spermatocyte; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metalloendopeptidase inhibitor activity;
Cellular component	integral component of membrane; membrane; extracellular exosome; extracellular space;
Biological process	negative regulation of cell population proliferation; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	5918
	109222
	ENSG00000118849
	ENSMUSG00000049404
	P49788
	n/a
	NM_002888; NM_206963
	NM_001164763
	NP_002879; NP_996846
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoic acid receptor responder protein 1 is a protein that in humans is encoded by the RARRES1 gene.^[5]^[6]^[7]

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118849 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049404 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagpal S, Patel S, Asano AT, Johnson AT, Duvic M, Chandraratna RA (May 1996). "Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin". J Invest Dermatol. 106 (2): 269–74. doi:10.1111/1523-1747.ep12340668. PMID 8601727.
^ Duvic M, Nagpal S, Asano AT, Chandraratna RA (Sep 1997). "Molecular mechanisms of tazarotene action in psoriasis". J Am Acad Dermatol. 37 (2 Pt 3): S18–24. doi:10.1016/s0190-9622(97)80396-9. PMID 9270552.
^ ^a ^b "Entrez Gene: RARRES1 retinoic acid receptor responder (tazarotene induced) 1".

Jing C, El-Ghany MA, Beesley C, et al. (2002). "Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity". J. Natl. Cancer Inst. 94 (7): 482–90. doi:10.1093/jnci/94.7.482. PMID 11929948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang J, Liu L, Pfeifer GP (2004). "Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene". Oncogene. 23 (12): 2241–9. doi:10.1038/sj.onc.1207328. PMID 14691453.
Youssef EM, Chen XQ, Higuchi E, et al. (2004). "Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers". Cancer Res. 64 (7): 2411–7. doi:10.1158/0008-5472.CAN-03-0164. PMID 15059893.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mizuiri H, Yoshida K, Toge T, et al. (2005). "DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage". Cancer Sci. 96 (9): 571–7. doi:10.1111/j.1349-7006.2005.00082.x. PMID 16128742.
Shutoh M, Oue N, Aung PP, et al. (2006). "DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation". Cancer. 104 (8): 1609–19. doi:10.1002/cncr.21392. PMID 16134180.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118849 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049404 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8601727-5] Nagpal S, Patel S, Asano AT, Johnson AT, Duvic M, Chandraratna RA (May 1996). "Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin". J Invest Dermatol. 106 (2): 269–74. doi:10.1111/1523-1747.ep12340668. PMID 8601727.

[pmid9270552-6] Duvic M, Nagpal S, Asano AT, Chandraratna RA (Sep 1997). "Molecular mechanisms of tazarotene action in psoriasis". J Am Acad Dermatol. 37 (2 Pt 3): S18–24. doi:10.1016/s0190-9622(97)80396-9. PMID 9270552.

[entrez-7] "Entrez Gene: RARRES1 retinoic acid receptor responder (tazarotene induced) 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

References

Further reading