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RARRES1

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RARRES1
Identifiers
AliasesRARRES1, LXNL, TIG1, PERG-1, retinoic acid receptor responder 1
External IDsOMIM: 605090; MGI: 1924461; HomoloGene: 2166; GeneCards: RARRES1; OMA:RARRES1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002888
NM_206963

NM_001164763

RefSeq (protein)

NP_002879
NP_996846

n/a

Location (UCSC)Chr 3: 158.7 – 158.73 MbChr 3: 67.39 – 67.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Retinoic acid receptor responder protein 1 is a protein that in humans is encoded by the RARRES1 gene.[5][6][7]

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118849Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049404Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagpal S, Patel S, Asano AT, Johnson AT, Duvic M, Chandraratna RA (May 1996). "Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin". J Invest Dermatol. 106 (2): 269–74. doi:10.1111/1523-1747.ep12340668. PMID 8601727.
  6. ^ Duvic M, Nagpal S, Asano AT, Chandraratna RA (Sep 1997). "Molecular mechanisms of tazarotene action in psoriasis". J Am Acad Dermatol. 37 (2 Pt 3): S18–24. doi:10.1016/s0190-9622(97)80396-9. PMID 9270552.
  7. ^ a b "Entrez Gene: RARRES1 retinoic acid receptor responder (tazarotene induced) 1".

Further reading