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GSTM1 Identifiers Aliases GSTM1 , GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1, glutathione S-transferase mu 1External IDs OMIM : 138350 ; MGI : 95861 ; HomoloGene : 121492 ; GeneCards : GSTM1 ; OMA :GSTM1 - orthologs Wikidata
Glutathione S -transferase Mu 1 (gene name GSTM1 ) is a human glutathione S -transferase .
Function
Cytosolic and membrane -bound forms of glutathione S -transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S -transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S -transferase that belongs to the mu class . The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens , therapeutic drugs , environmental toxins , and products of oxidative stress , by conjugation with glutathione .
The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3, and are known to be highly polymorphic . These genetic variations can change an individual's susceptibility to carcinogens and toxins, as well as affect the toxicity and efficacy of certain drugs . Null mutations of this class mu gene have been linked with an increase in a number of cancers , likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.[5]
References
Further reading
Engel LS, Taioli E, Pfeiffer R, Garcia-Closas M, Marcus PM, Lan Q, et al. (July 2002). "Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review" . American Journal of Epidemiology . 156 (2): 95–109. doi :10.1093/aje/kwf018 . PMID 12117698 .
Navarro SL, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW (November 2009). "Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes" . Cancer Epidemiology, Biomarkers & Prevention . 18 (11): 2974–8. doi :10.1158/1055-9965.EPI-09-0701 . PMC 2777676 . PMID 19900941 .
External links
PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione S -transferase Mu 1
PDB gallery
1gtu : LIGAND-FREE HUMAN GLUTATHIONE S-TRANSFERASE M1A-1A
1xw6 : 1.9 angstrom resolution structure of human glutathione S-transferase M1A-1A complexed with glutathione
1xwk : 2.3 angstrom resolution crystal structure of human glutathione S-transferase M1A-1A complexed with glutathionyl-S-dinitrobenzene
1yj6 : crystal structure of human glutathione S-transferase M1A-1A complexed with glutathionyl-zinc-trihydroxide
2f3m : Structure of human GLUTATHIONE S-TRANSFERASE M1A-1A complexed with 1-(S-(GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXADIENATE ANION