From Wikipedia, the free encyclopedia
Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene .[ 5] [ 6] [ 7]
Interactions
RRAS2 has been shown to interact with C-Raf .[ 8] [ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000133818 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055723 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line" . Mol Cell Biol . 10 (4): 1793–8. PMC 362288 PMID 2108320 . ^ Chan AM, Miki T, Meyers KA, Aaronson SA (September 1994). "A human oncogene of the RAS superfamily unmasked by expression cDNA cloning" . Proc Natl Acad Sci U S A . 91 (16): 7558–62. Bibcode :1994PNAS...91.7558C . doi :10.1073/pnas.91.16.7558 . PMC 44441 PMID 8052619 . ^ "Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2" .^ Li, W; Han M; Guan K L (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf" . Genes Dev . 14 (8). UNITED STATES: 895–900. ISSN 0890-9369 . PMC 316541 PMID 10783161 . ^ Movilla, N; Crespo P; Bustelo X R (October 1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins" . Oncogene . 18 (43). ENGLAND: 5860–9. doi :10.1038/sj.onc.1202968 ISSN 0950-9232 . PMID 10557073 .
Further reading
Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW (2002). "Ras and relatives--job sharing and networking keep an old family together". Exp. Hematol . 30 (10): 1089–106. doi :10.1016/S0301-472X(02)00904-9 . PMID 12384139 . Rosário M, Paterson HF, Marshall CJ (1999). "Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells" . EMBO J . 18 (5): 1270–9. doi :10.1093/emboj/18.5.1270 . PMC 1171217 PMID 10064593 . Linnemann T, Geyer M, Jaitner BK, et al. (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily" . J. Biol. Chem . 274 (19): 13556–62. doi :10.1074/jbc.274.19.13556 PMID 10224125 . Ehrhardt GR, Leslie KB, Lee F, et al. (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood . 94 (7): 2433–44. PMID 10498616 . Movilla N, Crespo P, Bustelo XR (1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins" . Oncogene . 18 (43): 5860–9. doi :10.1038/sj.onc.1202968 PMID 10557073 . Ohba Y, Mochizuki N, Yamashita S, et al. (2000). "Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3" . J. Biol. Chem . 275 (26): 20020–6. doi :10.1074/jbc.M000981200 PMID 10777492 . Figueroa C, Taylor J, Vojtek AB (2001). "Prenylated Rab acceptor protein is a receptor for prenylated small GTPases" . J. Biol. Chem . 276 (30): 28219–25. doi :10.1074/jbc.M101763200 PMID 11335720 . Murphy GA, Graham SM, Morita S, et al. (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation" . J. Biol. Chem . 277 (12): 9966–75. doi :10.1074/jbc.M109059200 PMID 11788587 . Rong R, He Q, Liu Y, et al. (2002). "TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway". Oncogene . 21 (7): 1062–70. doi :10.1038/sj.onc.1205154 . PMID 11850823 . Ortiz-Vega S, Khokhlatchev A, Nedwidek M, et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1" . Oncogene . 21 (9): 1381–90. doi :10.1038/sj.onc.1205192 PMID 11857081 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics . 81 (2): 112–25. doi :10.1016/S0888-7543(02)00008-3 . PMID 12620389 . Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization" . J. Biol. Chem . 279 (21): 22353–61. doi :10.1074/jbc.M312867200 PMID 15031288 . Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (34): 12479–84. Bibcode :2004PNAS..10112479K . doi :10.1073/pnas.0403413101 . PMC 515085 PMID 15308774 . Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Res . 14 (9): 1711–8. doi :10.1101/gr.2435604 . PMC 515316 PMID 15342556 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–5. Bibcode :2005Sci...307.1621B . doi :10.1126/science.1105776 . PMID 15761153 .
