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INPP5B

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INPP5B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesINPP5B, 5PTase, inositol polyphosphate-5-phosphatase B
External IDsOMIM: 147264; MGI: 103257; HomoloGene: 69021; GeneCards: INPP5B; OMA:INPP5B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001297434
NM_005540
NM_001350227
NM_001350228

NM_008385

RefSeq (protein)

NP_032411

Location (UCSC)Chr 1: 37.86 – 37.95 MbChr 4: 124.64 – 124.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.[5][6]

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204084Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028894Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ross TS, Jefferson AB, Mitchell CA, Majerus PW (Dec 1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J Biol Chem. 266 (30): 20283–9. PMID 1718960.
  6. ^ a b "Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa".

Further reading