KDM6B

KDM6B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XUE, 2XXZ, 4ASK, 5FP3
Identifiers
Aliases	KDM6B, JMJD3, lysine demethylase 6B, NEDCFSA
External IDs	OMIM: 611577; MGI: 2448492; HomoloGene: 18945; GeneCards: KDM6B; OMA:KDM6B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,854,796 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,413,675 bp
RNA expression pattern
	Top expressed in
	blood; ; sural nerve; ; granulocyte; ; epithelium of colon; ; mucosa of ileum; ; left ovary; ; right ovary; ; ganglionic eminence; ; anterior pituitary; ; left uterine tube;
	Top expressed in
	internal carotid artery; ; Rostral migratory stream; ; external carotid artery; ; otolith organ; ; utricle; ; hand; ; secondary oocyte; ; vestibular membrane of cochlear duct; ; primitive streak; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; beta-catenin binding; chromatin binding; dioxygenase activity; metal ion binding; protein binding; oxidoreductase activity; histone demethylase activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin DNA binding;
Cellular component	nucleoplasm; nucleus; MLL3/4 complex;
Biological process	response to fungicide; histone demethylation; cell fate commitment; inflammatory response to antigenic stimulus; cardiac muscle cell differentiation; response to activity; mesodermal cell differentiation; regulation of gene expression; endothelial cell differentiation; inflammatory response; hippocampus development; positive regulation of transcription by RNA polymerase II; cellular response to hydrogen peroxide; histone H3-K27 demethylation; chromatin remodeling; chromatin organization; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	23135
	216850
	ENSG00000132510
	ENSMUSG00000018476
	O15054
	Q5NCY0
	NM_001080424; NM_001348716
	NM_001017426
	NP_001073893; NP_001335645
	NP_001017426
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B gene. ^[5]

Regulation during differentation

KDM6B was found to be expressional increased during cardiac and endothelial differentation of murine embryonic stem cells.^[6]

Small molecule inhibition

A small molecule inhibition (GSK-J1) has been developed to inhibit jumonji domain of KDM6 histone demethylase family to modulate proinflammatory response in macrophage.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132510 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018476 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Lysine demethylase 6B". Retrieved 2016-04-09.
^ Boeckel, Jes-Niels; Derlet, Anja; Glaser, Simone F.; Luczak, Annika; Lucas, Tina; Heumüller, Andreas W.; Krüger, Marcus; Zehendner, Christoph M.; Kaluza, David (July 2016). "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 36 (7): 1425–1433. doi:10.1161/ATVBAHA.116.307695. ISSN 1524-4636. PMID 27199445.
^ Kruidenier, Laurens; Chung, Chun-wa; Cheng, Zhongjun; Liddle, John; Che, KaHing; Joberty, Gerard; Bantscheff, Marcus; Bountra, Chas; Bridges, Angela (2012-08-16). "A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response". Nature. 488 (7411): 404–408. Bibcode:2012Natur.488..404K. doi:10.1038/nature11262. ISSN 1476-4687. PMC 4691848. PMID 22842901.

Regulation during differentation

Small molecule inhibition

References

Further reading