IKZF4

IKZF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MA7
Identifiers
Aliases	IKZF4, EOS, ZNFN1A4, IKAROS family zinc finger 4
External IDs	OMIM: 606239; MGI: 1343139; HomoloGene: 69103; GeneCards: IKZF4; OMA:IKZF4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,038,435 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,505,227 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; left adrenal gland; ; adrenal cortex; ; left adrenal cortex; ; right adrenal gland; ; inferior ganglion of vagus nerve; ; muscle of thigh; ; right adrenal cortex; ; testicle; ; gastrocnemius muscle;
	Top expressed in
	Rostral migratory stream; ; secondary oocyte; ; zygote; ; primary oocyte; ; medulla of thymus; ; female urethra; ; trigeminal ganglion; ; suprachiasmatic nucleus; ; supraoptic nucleus; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; nucleic acid binding; sequence-specific DNA binding; DNA binding; bHLH transcription factor binding; protein homodimerization activity; metal ion binding; protein heterodimerization activity; zinc ion binding; protein domain specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; nuclear body; protein-containing complex;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; protein homooligomerization; protein heterooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	64375
	22781
	ENSG00000123411
	ENSMUSG00000002578
	Q9H2S9
	Q8C208
	NM_022465; NM_001351089; NM_001351090; NM_001351091; NM_001351092
	NM_011772; NM_001358536; NM_001358537
	NP_071910; NP_001338018; NP_001338019; NP_001338020; NP_001338021
	NP_035902; NP_001345465; NP_001345466
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.^[5]^[6]

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]^[6]

Interactions

IKZF4 has been shown to interact with CTBP1^[7] and IKZF1.^[5]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123411 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002578 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
^ ^a ^b "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)".
^ Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. 269 (23). Germany: 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. ISSN 0014-2956. PMID 12444977.
^ Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. 447 (1). NETHERLANDS: 76–80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586.

Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Bao J; Lin H; Ouyang Y; et al. (2005). "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos". Nat. Neurosci. 7 (11): 1250–8. doi:10.1038/nn1342. PMID 15494726. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Perdomo J, Crossley M (2003). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. PMID 12444977.
Koipally J, Georgopoulos K (2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
Nagase T; Nakayama M; Nakajima D; et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Honma Y; Kiyosawa H; Mori T; et al. (1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. PMID 10218586. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123411 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002578 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10978333-5] Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.

[entrez-6] "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)".

[pmid12444977-7] Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. 269 (23). Germany: 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. ISSN 0014-2956. PMID 12444977.

[pmid10218586-8] Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. 447 (1). NETHERLANDS: 76–80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586.

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Interactions

References

Further reading