Phospholipase A-2-activating protein

PLAA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K89, 2K8A, 2K8B, 2K8C, 3EBB
Identifiers
Aliases	PLAA, DOA1, PLA2P, PLAP, phospholipase A2 activating protein, NDMSBA
External IDs	OMIM: 603873; MGI: 104810; HomoloGene: 3138; GeneCards: PLAA; OMA:PLAA - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	26,947,242 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	94,491,481 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; secondary oocyte; ; stromal cell of endometrium; ; muscle of thigh; ; testicle; ; ganglionic eminence; ; monocyte; ; ventricular zone; ; gonad; ; Achilles tendon;
	Top expressed in
	tail of embryo; ; genital tubercle; ; zygote; ; secondary oocyte; ; epiblast; ; medial ganglionic eminence; ; Gonadal ridge; ; mandibular prominence; ; primitive streak; ; somite;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; phospholipase A2 activator activity; ubiquitin binding;
Cellular component	extracellular exosome; cytoplasm; nucleus; synapse; cell junction;
Biological process	phospholipid metabolic process; inflammatory response; signal transduction; ubiquitin recycling; proteasome-mediated ubiquitin-dependent protein catabolic process; macroautophagy; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; cellular response to lipopolysaccharide; negative regulation of protein K63-linked ubiquitination; positive regulation of synaptic vesicle recycling; positive regulation of dendrite extension; positive regulation of neuron migration; prostaglandin metabolic process; multicellular organism development; nervous system development; positive regulation of phospholipase A2 activity;
	Sources:Amigo / QuickGO
Orthologs
	9373
	18786
	ENSG00000137055
	ENSMUSG00000028577
	Q9Y263
	P27612
	NM_001031689; NM_004253; NM_001321546
	NM_172695
	NP_001026859; NP_001308475
	NP_766283
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137055 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028577 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chopra AK, Ribardo DA, Wood TG, Prusak DJ, Xu XJ, Peterson JW (Mar 1999). "Molecular characterization of cDNA for phospholipase A2-activating protein". Biochim Biophys Acta. 1444 (1): 125–30. doi:10.1016/s0167-4781(98)00249-8. PMID 9931468.
^ Beatty BG, Qi S, Pienkowska M, Herbrick JA, Scheidl T, Zhang ZM, Kola I, Scherer SW, Seth A (Mar 2000). "Chromosomal localization of phospholipase A2 activating protein, an Ets2 target gene, to 9p21". Genomics. 62 (3): 529–32. doi:10.1006/geno.1999.5999. PMID 10644453.
^ "Entrez Gene: PLAA phospholipase A2-activating protein".

Clark MA, Ozgür LE, Conway TM, et al. (1991). "Cloning of a phospholipase A2-activating protein". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5418–22. doi:10.1073/pnas.88.12.5418. PMC 51884. PMID 2052621.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ruiz A, Nadal M, Puig S, Estivill X (1999). "Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region". Gene. 239 (1): 155–61. doi:10.1016/S0378-1119(99)00354-6. PMID 10571045.
Seigneurin-Berny D, Verdel A, Curtet S, et al. (2001). "Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways". Mol. Cell. Biol. 21 (23): 8035–44. doi:10.1128/MCB.21.23.8035-8044.2001. PMC 99970. PMID 11689694.
Kozlenkov A, Manes T, Hoylaerts MF, Millán JL (2002). "Function assignment to conserved residues in mammalian alkaline phosphatases". J. Biol. Chem. 277 (25): 22992–9. doi:10.1074/jbc.M202298200. PMID 11937510.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Koumanov K, Momchilova A, Wolf C (2004). "Bimodal regulatory effect of melittin and phospholipase A2-activating protein on human type II secretory phospholipase A2". Cell Biol. Int. 27 (10): 871–7. doi:10.1016/S1065-6995(03)00176-8. PMID 14499668.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137055 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028577 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9931468-5] Chopra AK, Ribardo DA, Wood TG, Prusak DJ, Xu XJ, Peterson JW (Mar 1999). "Molecular characterization of cDNA for phospholipase A2-activating protein". Biochim Biophys Acta. 1444 (1): 125–30. doi:10.1016/s0167-4781(98)00249-8. PMID 9931468.

[pmid10644453-6] Beatty BG, Qi S, Pienkowska M, Herbrick JA, Scheidl T, Zhang ZM, Kola I, Scherer SW, Seth A (Mar 2000). "Chromosomal localization of phospholipase A2 activating protein, an Ets2 target gene, to 9p21". Genomics. 62 (3): 529–32. doi:10.1006/geno.1999.5999. PMID 10644453.

[entrez-7] "Entrez Gene: PLAA phospholipase A2-activating protein".

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References

Further reading