EIF3CL

EIF3CL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J8B, 3J8C
Identifiers
Aliases	EIF3CL, eukaryotic translation initiation factor 3 subunit C like
External IDs	MGI: 1926966; GeneCards: EIF3CL; OMA:EIF3CL - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	28,403,841 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,165,583 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; left ventricle; ; mucosa of transverse colon; ; epithelium of colon; ; right auricle; ; skeletal muscle tissue; ; gastrocnemius muscle; ; anterior cingulate cortex; ; hippocampus proper; ; gonad;
	Top expressed in
	tail of embryo; ; genital tubercle; ; mandibular prominence; ; maxillary prominence; ; somite; ; endothelial cell of lymphatic vessel; ; Gonadal ridge; ; hair follicle; ; primitive streak; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation initiation factor binding; translation initiation factor activity; RNA binding;
Cellular component	cytoplasm; eukaryotic translation initiation factor 3 complex; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex;
Biological process	translational initiation; protein biosynthesis; formation of cytoplasmic translation initiation complex; cytoplasmic translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	728689
	56347
	ENSG00000205609
	ENSMUSG00000030738
	B5ME19
	Q8R1B4
	NM_001099661; NM_001317856; NM_001317857
	NM_146200
	NP_001093131; NP_001304785; NP_001304786
	NP_666312
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 3 subunit C like is a protein that in humans is encoded by the EIF3CL gene. ^[5]

Function

The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205609 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030738 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Eukaryotic translation initiation factor 3 subunit C like". Retrieved 2020-04-15.

EIF3CL

Function

See also

References

Further reading