Neuropilin 2

NRP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QQJ, 2QQK, 2QQL, 2QQO, 4QDQ, 4QDR, 4QDS, 5DN2
Identifiers
Aliases	NRP2, NP2, NPN2, PRO2714, VEGF165R2, neuropilin 2
External IDs	OMIM: 602070; MGI: 1100492; HomoloGene: 2875; GeneCards: NRP2; OMA:NRP2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.3 Start 205,681,990 bp End 205,798,133 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C2 Start 62,742,444 bp End 62,857,854 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastric mucosa epithelium of colon muscle layer of sigmoid colon cartilage tissue body of uterus Achilles tendon smooth muscle tissue gallbladder left ovary Top expressed in calvaria body of femur habenula epithelium of bronchiole stroma of bone marrow dermis genital tubercle olfactory tubercle hair follicle tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vascular endothelial growth factor-activated receptor activity heparin binding semaphorin receptor activity growth factor binding metal ion binding cytokine binding protein binding identical protein binding signaling receptor activity Cellular component integral component of membrane membrane plasma membrane semaphorin receptor complex extracellular region axon glutamatergic synapse integral component of postsynaptic membrane Biological process sympathetic ganglion development cell differentiation semaphorin-plexin signaling pathway involved in neuron projection guidance positive regulation of endothelial cell proliferation vascular endothelial growth factor signaling pathway nervous system development axon guidance positive regulation of endothelial cell migration multicellular organism development sympathetic neuron projection guidance vascular endothelial growth factor receptor signaling pathway cell adhesion angiogenesis nerve development sympathetic neuron projection extension axon extension involved in axon guidance outflow tract septum morphogenesis neural crest cell migration neuron migration heart development facial nerve structural organization vestibulocochlear nerve structural organization gonadotrophin-releasing hormone neuronal migration to the hypothalamus ventral trunk neural crest cell migration negative chemotaxis trigeminal ganglion development sensory neuron axon guidance neural crest cell migration involved in autonomic nervous system development facioacoustic ganglion development dorsal root ganglion morphogenesis cellular response to leukemia inhibitory factor regulation of postsynapse organization viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8828 18187 Ensembl ENSG00000118257 ENSMUSG00000025969 UniProt O60462 O35375 RefSeq (mRNA) NM_003872 NM_018534 NM_201264 NM_201266 NM_201267 NM_201279 NM_001077403 NM_001077404 NM_001077405 NM_001077406 NM_001077407 NM_010939 RefSeq (protein) NP_003863 NP_061004 NP_957716 NP_957718 NP_957719 NP_958436 NP_001070871 NP_001070872 NP_001070873 NP_001070874 NP_001070875 NP_035069 Location (UCSC) Chr 2: 205.68 – 205.8 Mb Chr 1: 62.74 – 62.86 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (1999). "Vascular endothelial growth factor (VEGF) and its receptors". FASEB J. 13 (1): 9–22. PMID 9872925.
• Kolodkin AL, Levengood DV, Rowe EG, et al. (1997). "Neuropilin is a semaphorin III receptor". Cell. 90 (4): 753–62. doi:10.1016/S0092-8674(00)80535-8. PMID 9288754.
• Giger RJ, Urquhart ER, Gillespie SK, et al. (1999). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. doi:10.1016/S0896-6273(00)80625-X. PMID 9856463.
• Chen H, He Z, Bagri A, Tessier-Lavigne M (1999). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins". Neuron. 21 (6): 1283–90. doi:10.1016/S0896-6273(00)80648-0. PMID 9883722.
• Takahashi T, Nakamura F, Jin Z, et al. (1999). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nat. Neurosci. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.
• Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively". Genomics. 57 (3): 459–60. doi:10.1006/geno.1999.5790. PMID 10329017.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
• Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". J. Biol. Chem. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.
• Handa A, Tokunaga T, Tsuchida T, et al. (2000). "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma". Int. J. Oncol. 17 (2): 291–5. doi:10.3892/ijo.17.2.291. PMID 10891538.
• Rossignol M, Gagnon ML, Klagsbrun M (2001). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms". Genomics. 70 (2): 211–22. doi:10.1006/geno.2000.6381. PMID 11112349.
• Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes". J. Biol. Chem. 276 (22): 18688–94. doi:10.1074/jbc.M006909200. PMID 11278319.
• Cohen T, Gluzman-Poltorak Z, Brodzky A, et al. (2001). "Neuroendocrine cells along the digestive tract express neuropilin-2". Biochem. Biophys. Res. Commun. 284 (2): 395–403. doi:10.1006/bbrc.2001.4958. PMID 11394892.
• Herzog Y, Kalcheim C, Kahane N, et al. (2002). "Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins". Mech. Dev. 109 (1): 115–9. doi:10.1016/S0925-4773(01)00518-4. PMID 11677062.
• Oh H, Takagi H, Otani A, et al. (2002). "Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 383–8. doi:10.1073/pnas.012074399. PMC 117569. PMID 11756651.
• Fakhari M, Pullirsch D, Abraham D, et al. (2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma". Cancer. 94 (1): 258–63. doi:10.1002/cncr.10177. PMID 11815985.
• Cohen T, Herzog Y, Brodzky A, et al. (2002). "Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours". J. Pathol. 198 (1): 77–82. doi:10.1002/path.1179. PMID 12210066.
• Kawakami T, Tokunaga T, Hatanaka H, et al. (2003). "Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma". Cancer. 95 (10): 2196–201. doi:10.1002/cncr.10936. PMID 12412174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.