Exosome component 5

EXOSC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC5, RRP41B, RRP46, Rrp46p, hRrp46p, p12B, Exosome component 5, CABAC
External IDs	OMIM: 606492; MGI: 107889; HomoloGene: 5981; GeneCards: EXOSC5; OMA:EXOSC5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.2 Start 41,386,371 bp End 41,397,362 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A3|7 13.96 cM Start 25,358,589 bp End 25,370,793 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte gastrocnemius muscle muscle of thigh body of pancreas gonad prefrontal cortex C1 segment right adrenal gland skin of abdomen skin of leg Top expressed in seminiferous tubule spermatid spermatocyte embryo yolk sac embryo morula morula epiblast right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3'-5'-exoribonuclease activity exoribonuclease activity protein binding RNA binding Cellular component cytoplasm cytosol exosome (RNase complex) nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) nucleolus nucleus nucleoplasm Biological process regulation of mRNA stability nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' rRNA 3'-end processing rRNA catabolic process DNA deamination nuclear mRNA surveillance defense response to virus exonucleolytic catabolism of deadenylated mRNA U4 snRNA 3'-end processing polyadenylation-dependent snoRNA 3'-end processing RNA catabolic process rRNA processing RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56915 27998 Ensembl ENSG00000077348 ENSMUSG00000061286 UniProt Q9NQT4 Q9CRA8 RefSeq (mRNA) NM_020158 NM_138586 RefSeq (protein) NP_064543 NP_613052 Location (UCSC) Chr 19: 41.39 – 41.4 Mb Chr 7: 25.36 – 25.37 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Exosome component 5, also known as EXOSC5, is a human gene, which is part of the exosome complex.

Interactions

Exosome component 5 has been shown to interact with:

• Exosome component 1, and
• Exosome component 8.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791.
• Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
• Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
• Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Yang XF, Wu CJ, Chen L, et al. (2002). "CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells". Cancer Res. 62 (19): 5517–22. PMID 12359762.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Zhou H, Zhang D, Wang Y, et al. (2006). "Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector". Biochem. Biophys. Res. Commun. 347 (1): 200–7. doi:10.1016/j.bbrc.2006.06.093. PMID 16815301.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.