EXOC1

EXOC1
Identifiers
Aliases	EXOC1, BM-102, SEC3, SEC3L1, SEC3P, exocyst complex component 1
External IDs	OMIM: 607879; MGI: 2445020; HomoloGene: 41241; GeneCards: EXOC1; OMA:EXOC1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q12 Start 55,853,648 bp End 55,905,086 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 C3.3|5 Start 76,529,311 bp End 76,570,294 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium skin of thigh skin of hip oral cavity Achilles tendon mucosa of sigmoid colon parietal pleura visceral pleura inferior olivary nucleus germinal epithelium Top expressed in neural layer of retina zygote secondary oocyte granulocyte tail of embryo dentate gyrus of hippocampal formation granule cell spermatocyte ventricular zone genital tubercle superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-4,5-bisphosphate binding protein binding Cellular component cytoplasmic side of apical plasma membrane cytosol plasma membrane membrane exocyst cytoplasm perinuclear region of cytoplasm Flemming body Biological process protein transport exocyst localization Golgi to plasma membrane transport regulation of macroautophagy phosphatidylinositol-mediated signaling positive regulation of protein secretion exocytosis transport viral process defense response to virus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55763 69940 Ensembl ENSG00000090989 ENSMUSG00000036435 UniProt Q9NV70 Q8R3S6 RefSeq (mRNA) NM_001024924 NM_018261 NM_178237 NM_001289770 NM_001289771 NM_027270 NM_001359370 NM_001359372 NM_001359373 RefSeq (protein) NP_001020095 NP_060731 NP_839955 NP_001276699 NP_001276700 NP_081546 NP_001346299 NP_001346301 NP_001346302 NP_001388254 NP_001388255 Location (UCSC) Chr 4: 55.85 – 55.91 Mb Chr 5: 76.53 – 76.57 Mb PubMed search
Wikidata
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Exocyst complex component 1 is a protein that in humans is encoded by the EXOC1 gene.

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Further reading

• Hsu SC, TerBush D, Abraham M, Guo W (2004). "The exocyst complex in polarized exocytosis". Int. Rev. Cytol. International Review of Cytology. 233: 243–65. doi:10.1016/S0074-7696(04)33006-8. ISBN 978-0-12-364637-8. PMID 15037366.
• Kee Y, Yoo JS, Hazuka CD, et al. (1998). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. doi:10.1073/pnas.94.26.14438. PMC 25013. PMID 9405631.
• Hsu SC, Hazuka CD, Roth R, et al. (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments". Neuron. 20 (6): 1111–22. doi:10.1016/S0896-6273(00)80493-6. PMID 9655500.
• Matern HT, Yeaman C, Nelson WJ, Scheller RH (2001). "The Sec6/8 complex in mammalian cells: Characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9648–53. doi:10.1073/pnas.171317898. PMC 55506. PMID 11493706.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Inoue M, Chang L, Hwang J, et al. (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. 422 (6932): 629–33. doi:10.1038/nature01533. hdl:2027.42/62982. PMID 12687004.
• Moskalenko S, Tong C, Rosse C, et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.