From Wikipedia, the free encyclopedia
Adipose triglyceride lipase also known as patatin-like phospholipase domain-containing protein 2 is an enzyme that in humans is encoded by the PNPLA2 gene .[5] [6] [7] [8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000177666 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025509 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 .
^ Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family" . J Lipid Res . 47 (9): 1940–9. doi :10.1194/jlr.M600185-JLR200 . PMID 16799181 .
^ Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions" . J Lipid Res . 50 Suppl (Supplement): S63–8. doi :10.1194/jlr.R800082-JLR200 . PMC 2674697 . PMID 19029121 . {{cite journal }}
: CS1 maint: unflagged free DOI (link )
^ "Entrez Gene: PNPLA2 patatin-like phospholipase domain containing 2" .
External links
Further reading
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 . PMID 9110174 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 . PMID 15231748 .
Villena JA, Roy S, Sarkadi-Nagy E, et al. (2004). "Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis" . J. Biol. Chem . 279 (45): 47066–75. doi :10.1074/jbc.M403855200 . PMID 15337759 .
Jenkins CM, Mancuso DJ, Yan W, et al. (2005). "Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities" . J. Biol. Chem . 279 (47): 48968–75. doi :10.1074/jbc.M407841200 . PMID 15364929 .
Zimmermann R, Strauss JG, Haemmerle G, et al. (2004). "Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase". Science . 306 (5700): 1383–6. doi :10.1126/science.1100747 . PMID 15550674 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 .
Smirnova E, Goldberg EB, Makarova KS, et al. (2006). "ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells" . EMBO Rep . 7 (1): 106–13. doi :10.1038/sj.embor.7400559 . PMC 1369222 . PMID 16239926 .
Schoenborn V, Heid IM, Vollmert C, et al. (2006). "The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes" . Diabetes . 55 (5): 1270–5. doi :10.2337/db05-1498 . PMID 16644682 .
Lass A, Zimmermann R, Haemmerle G, et al. (2007). "Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome". Cell Metab . 3 (5): 309–19. doi :10.1016/j.cmet.2006.03.005 . PMID 16679289 .
Mairal A, Langin D, Arner P, Hoffstedt J (2007). "Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity" . Diabetologia . 49 (7): 1629–36. doi :10.1007/s00125-006-0272-x . PMID 16752181 .
Notari L, Baladron V, Aroca-Aguilar JD, et al. (2007). "Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor" . J. Biol. Chem . 281 (49): 38022–37. doi :10.1074/jbc.M600353200 . PMID 17032652 .
Fischer J, Lefèvre C, Morava E, et al. (2007). "The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy". Nat. Genet . 39 (1): 28–30. doi :10.1038/ng1951 . PMID 17187067 .
Rydén M, Jocken J, van Harmelen V, et al. (2007). "Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis". Am. J. Physiol. Endocrinol. Metab . 292 (6): E1847–55. CiteSeerX 10.1.1.328.3523 . doi :10.1152/ajpendo.00040.2007 . PMID 17327373 .
Jocken JW, Langin D, Smit E, et al. (2007). "Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state" . J. Clin. Endocrinol. Metab . 92 (6): 2292–9. doi :10.1210/jc.2006-1318 . PMID 17356053 .
Steinberg GR, Kemp BE, Watt MJ (2007). "Adipocyte triglyceride lipase expression in human obesity". Am. J. Physiol. Endocrinol. Metab . 293 (4): E958–64. doi :10.1152/ajpendo.00235.2007 . PMID 17609260 .
Fischer J, Negre-Salvayre A, Salvayre R (2007). "[Neutral lipid storage diseases and ATGL (adipose triglyceride lipase) and CGI-58/ABHD5 (alpha-beta hydrolase domain-containing 5) deficiency: myopathy, ichthyosis, but no obesity]" . Med Sci (Paris) . 23 (6–7): 575–8. doi :10.1051/medsci/20072367575 . PMID 17631826 .