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RNF4

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RNF4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF4, SLX5, SNURF, RES4-26, ring finger protein 4
External IDsOMIM: 602850; MGI: 1201691; HomoloGene: 37711; GeneCards: RNF4; OMA:RNF4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002938
NM_001185009
NM_001185010

NM_011278
NM_001304269
NM_001304270

RefSeq (protein)

NP_001171938
NP_001171939
NP_002929

NP_001291198
NP_001291199
NP_035408

Location (UCSC)Chr 4: 2.46 – 2.63 MbChr 5: 34.49 – 34.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene.[5][6]

The protein encoded by this gene contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.[6]

Interactions

RNF4 has been shown to interact with TCF20,[7] PATZ1[8][9] and Androgen receptor.[9][10][11]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000063978Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029110Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chiariotti L, Benvenuto G, Fedele M, Santoro M, Simeone A, Fusco A, Bruni CB (Jan 1998). "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3". Genomics. 47 (2): 258–65. doi:10.1006/geno.1997.5105. PMID 9479498.
  6. ^ a b "Entrez Gene: RNF4 ring finger protein 4".
  7. ^ Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (Aug 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–9. doi:10.1074/jbc.M003405200. PMID 10849425.
  8. ^ Fedele M, Benvenuto G, Pero R, Majello B, Battista S, Lembo F, Vollono E, Day PM, Santoro M, Lania L, Bruni CB, Fusco A, Chiariotti L (Mar 2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor". The Journal of Biological Chemistry. 275 (11): 7894–901. doi:10.1074/jbc.275.11.7894. PMID 10713105.
  9. ^ a b Pero R, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A, Bruni CB, Chiariotti L (Feb 2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription". The Journal of Biological Chemistry. 277 (5): 3280–5. doi:10.1074/jbc.M109491200. PMID 11719514.
  10. ^ Moilanen AM, Poukka H, Karvonen U, Häkli M, Jänne OA, Palvimo JJ (Sep 1998). "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription". Molecular and Cellular Biology. 18 (9): 5128–39. doi:10.1128/mcb.18.9.5128. PMC 109098. PMID 9710597.
  11. ^ Poukka H, Aarnisalo P, Santti H, Jänne OA, Palvimo JJ (Jan 2000). "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms". The Journal of Biological Chemistry. 275 (1): 571–9. doi:10.1074/jbc.275.1.571. PMID 10617653.

Further reading