ARHGEF5

ARHGEF5
Identifiers
Aliases	ARHGEF5, GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5
External IDs	OMIM: 600888; MGI: 1858952; HomoloGene: 66300; GeneCards: ARHGEF5; OMA:ARHGEF5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q35 Start 144,355,288 bp End 144,380,632 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B2.1 Start 43,242,516 bp End 43,266,254 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen mucosa of transverse colon left lobe of thyroid gland right lobe of thyroid gland duodenum minor salivary glands human kidney body of pancreas prostate Top expressed in skin of external ear epithelium of stomach duodenum lip jejunum large intestine colon pyloric antrum mucous cell of stomach left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTP binding protein binding lipid binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cell projection plasma membrane nucleoplasm cell junction podosome nucleus cell periphery cytosol Biological process intracellular signal transduction regulation of actin cytoskeleton organization positive regulation of JUN kinase activity regulation of GTPase activity positive regulation of DNA-binding transcription factor activity positive regulation of podosome assembly myeloid dendritic cell chemotaxis positive regulation of GTPase activity positive regulation of protein import regulation of ERK1 and ERK2 cascade regulation of Rho protein signal transduction regulation of cytoskeleton organization actin cytoskeleton organization positive regulation of stress fiber assembly positive regulation of apoptotic process regulation of small GTPase mediated signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7984 54324 Ensembl ENSG00000050327 ENSMUSG00000033542 UniProt Q12774 E9Q7D5 RefSeq (mRNA) NM_001002861 NM_005435 NM_133674 RefSeq (protein) NP_005426 NP_598435 Location (UCSC) Chr 7: 144.36 – 144.38 Mb Chr 6: 43.24 – 43.27 Mb PubMed search
Wikidata
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Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.

External links

• Human ARHGEF5 genome location and ARHGEF5 gene details page in the UCSC Genome Browser.

Further reading

• Snyder JT, Worthylake DK, Rossman KL, et al. (2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nat. Struct. Biol. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Umetsu DT, Dekruyff RH (2005). "Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment". Ann. N. Y. Acad. Sci. 1029 (1): 88–93. doi:10.1196/annals.1309.012. PMID 15681748.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.