PDS5A

PDS5A
Identifiers
Aliases	PDS5A, SCC-112, SCC112, PIG54, PDS5 cohesin associated factor A
External IDs	OMIM: 613200; MGI: 1918771; HomoloGene: 22877; GeneCards: PDS5A; OMA:PDS5A - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	39,977,956 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	65,855,616 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; epithelium of nasopharynx; ; Achilles tendon; ; tonsil; ; gingival epithelium; ; epithelium of colon; ; Epithelium of choroid plexus; ; cartilage tissue; ; seminal vesicula; ; bone marrow cells;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; epiblast; ; primitive streak; ; thymus; ; lacrimal gland; ; cumulus cell; ; renal corpuscle; ; Paneth cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; chromatin; plasma membrane; chromosome, centromeric region; nucleoplasm; chromosome; nucleus;
Biological process	cell division; cell cycle; negative regulation of DNA replication; mitotic sister chromatid cohesion; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	23244
	71521
	ENSG00000121892
	ENSMUSG00000029202
	Q29RF7
	Q6A026
	NM_001100399; NM_001100400; NM_015200
	NM_001081321; NM_027818
	NP_001093869; NP_001093870
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Sister chromatid cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121892 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029202 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (Dec 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
^ Losada A, Yokochi T, Hirano T (May 2005). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". J Cell Sci. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.
^ "Entrez Gene: SCC-112 SCC-112 protein".

Ishikawa K; Nagase T; Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gregson HC; Schmiesing JA; Kim JS; et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly". J. Biol. Chem. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kumar D; Sakabe I; Patel S; et al. (2004). "SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas". Gene. 328: 187–96. doi:10.1016/j.gene.2003.12.013. PMID 15019998. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rankin S, Ayad NG, Kirschner MW (2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol. Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
Ewing RM; Chu P; Elisma F; et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121892 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029202 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11076961-5] Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (Dec 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.

[pmid15855230-6] Losada A, Yokochi T, Hirano T (May 2005). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". J Cell Sci. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.

[entrez-7] "Entrez Gene: SCC-112 SCC-112 protein".

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References

Further reading