LDB2

LDB2
Identifiers
Aliases	LDB2, CLIM1, LDB1, LDB-2, LIM domain binding 2
External IDs	OMIM: 603450; MGI: 894670; HomoloGene: 989; GeneCards: LDB2; OMA:LDB2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4p15.32 Start 16,501,541 bp End 16,898,678 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B3 Start 44,629,474 bp End 44,957,022 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung Brodmann area 23 middle temporal gyrus body of uterus superior frontal gyrus vena cava Brodmann area 10 primary visual cortex frontal pole Achilles tendon Top expressed in Gonadal ridge subiculum genital tubercle vas deferens lumbar spinal ganglion dorsomedial hypothalamic nucleus ventromedial nucleus left lung Region I of hippocampus proper left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding LIM domain binding transcription coregulator activity protein binding Cellular component nucleus transcription regulator complex cell leading edge nucleolus plasma membrane Biological process regulation of transcription by RNA polymerase II hair follicle development positive regulation of cellular component biogenesis epithelial structure maintenance somatic stem cell population maintenance positive regulation of transcription by RNA polymerase II regulation of kinase activity regulation of cell migration negative regulation of transcription by RNA polymerase II multicellular organism development negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9079 16826 Ensembl ENSG00000169744 ENSMUSG00000039706 UniProt O43679 O55203 RefSeq (mRNA) NM_001130834 NM_001290 NM_001304434 NM_001304435 NM_001077398 NM_001286348 NM_010698 NM_001347349 NM_001359070 NM_001359071 RefSeq (protein) NP_001124306 NP_001281 NP_001291363 NP_001291364 NP_001070866 NP_001273277 NP_001334278 NP_034828 NP_001345999 NP_001346000 Location (UCSC) Chr 4: 16.5 – 16.9 Mb Chr 5: 44.63 – 44.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

LIM domain-binding protein 2 is a protein that in humans is encoded by the LDB2 gene.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Semina EV, Altherr MR, Murray JC (1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm. Genome. 9 (11): 921–4. doi:10.1007/s003359900899. PMID 9799849.
• Ueki N, Seki N, Yano K, et al. (1999). "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2". J. Hum. Genet. 44 (2): 112–5. doi:10.1007/s100380050120. PMID 10083735.
• Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.