RASGEF1A

RASGEF1A
Identifiers
Aliases	RASGEF1A, CG4853, RasGEF domain family member 1A
External IDs	OMIM: 614531; MGI: 1917977; HomoloGene: 17067; GeneCards: RASGEF1A; OMA:RASGEF1A - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	43,267,065 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	118,068,507 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; entorhinal cortex; ; Brodmann area 46; ; postcentral gyrus; ; superior frontal gyrus; ; external globus pallidus; ; cerebellar vermis; ; pars compacta;
	Top expressed in
	piriform cortex; ; olfactory tubercle; ; superior frontal gyrus; ; visual cortex; ; anterior amygdaloid area; ; nucleus accumbens; ; lateral septal nucleus; ; primary visual cortex; ; primary motor cortex; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity;
Cellular component	cytosol;
Biological process	positive regulation of Ras protein signal transduction; cell migration; MAPK cascade; small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	221002
	70727
	ENSG00000198915
	ENSMUSG00000030134
	Q8N9B8
	n/a
	NM_001282862; NM_145313
	NM_027526; NM_001316749; NM_001362103; NM_001362104; NM_001362105
	NP_001269791; NP_660356
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

RasGEF domain family, member 1A is a protein that in humans is encoded by the RASGEF1A gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198915 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030134 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RasGEF domain family, member 1A".

Ura K, Obama K, Satoh S, Sakai Y, Nakamura Y, Furukawa Y (Nov 2006). "Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma". Clinical Cancer Research. 12 (22): 6611–6. doi:10.1158/1078-0432.CCR-06-0783. PMID 17121879.
Emison ES, McCallion AS, Kashuk CS, Bush RT, Grice E, Lin S, Portnoy ME, Cutler DJ, Green ED, Chakravarti A (Apr 2005). "A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk". Nature. 434 (7035): 857–63. doi:10.1038/nature03467. PMID 15829955.
Garcia-Barcelo MM, Tang CS, Ngan ES, Lui VC, Chen Y, So MT, Leon TY, Miao XP, Shum CK, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KM, Wong KK, Cherny SS, Sham PC, Tam PK (Feb 2009). "Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2694–9. doi:10.1073/pnas.0809630105. PMC 2650328. PMID 19196962.
Yaman E, Gasper R, Koerner C, Wittinghofer A, Tazebay UH (Aug 2009). "RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange". The FEBS Journal. 276 (16): 4607–16. doi:10.1111/j.1742-4658.2009.07166.x. hdl:11693/22668. PMID 19645719.
Burzynski GM, Nolte IM, Bronda A, Bos KK, Osinga J, Plaza Menacho I, Twigt B, Maas S, Brooks AS, Verheij JB, Buys CH, Hofstra RM (May 2005). "Identifying candidate Hirschsprung disease-associated RET variants". American Journal of Human Genetics. 76 (5): 850–8. doi:10.1086/429589. PMC 1199373. PMID 15759212.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198915 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030134 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RasGEF domain family, member 1A".

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References

Further reading