CENTB1

ACAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JUE, 3T9K, 4CKG, 4CKH, 4F1P, 4NSW
Identifiers
Aliases	ACAP1, CENTB1, ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
External IDs	OMIM: 607763; MGI: 2388270; HomoloGene: 22835; GeneCards: ACAP1; OMA:ACAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,351,477 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,786,365 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; lymph node; ; spleen; ; bone marrow cells; ; left testis; ; right testis; ; appendix; ; nucleus accumbens; ; Pituitary Gland;
	Top expressed in
	granulocyte; ; thymus; ; blood; ; lymph node; ; mesenteric lymph nodes; ; spleen; ; pharynx; ; bone marrow; ; subcutaneous adipose tissue; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; GTPase activator activity;
Cellular component	endosome; recycling endosome membrane; membrane; intracellular membrane-bounded organelle;
Biological process	protein transport; positive regulation of GTPase activity; transport;
	Sources:Amigo / QuickGO
Orthologs
	9744
	216859
	ENSG00000072818; ENSG00000288169
	ENSMUSG00000001588
	Q15027
	Q8K2H4
	NM_014716
	NM_153788
	NP_055531
	NP_722483
	Wikidata
View/Edit Human	View/Edit Mouse

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ACAP1 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c ENSG00000288169 GRCh38: Ensembl release 89: ENSG00000072818, ENSG00000288169 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001588 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jackson TR, Kearns BG, Theibert AB (Dec 2000). "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling". Trends Biochem Sci. 25 (10): 489–95. doi:10.1016/S0968-0004(00)01644-3. PMID 11050434.
^ Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151 (3): 627–38. doi:10.1083/jcb.151.3.627. PMC 2185579. PMID 11062263.
^ "Entrez Gene: CENTB1 centaurin, beta 1".

External links

Human ACAP1 genome location and ACAP1 gene details page in the UCSC Genome Browser.

Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dai J, Li J, Bos E, et al. (2004). "ACAP1 promotes endocytic recycling by recognizing recycling sorting signals". Dev. Cell. 7 (5): 771–6. doi:10.1016/j.devcel.2004.10.002. PMID 15525538.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
Yamamoto-Furusho JK, Barnich N, Xavier R, et al. (2007). "Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation". J. Biol. Chem. 281 (47): 36060–70. doi:10.1074/jbc.M602383200. PMID 17005562.
Shinozaki-Narikawa N, Kodama T, Shibasaki Y (2007). "Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation". Traffic. 7 (11): 1539–50. doi:10.1111/j.1600-0854.2006.00480.x. PMID 17010122.
Li J, Peters PJ, Bai M, et al. (2007). "An ACAP1-containing clathrin coat complex for endocytic recycling". J. Cell Biol. 178 (3): 453–64. doi:10.1083/jcb.200608033. PMC 2064835. PMID 17664335.

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[refGRCh38Ensembl-1] ENSG00000288169 GRCh38: Ensembl release 89: ENSG00000072818, ENSG00000288169 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001588 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11050434-5] Jackson TR, Kearns BG, Theibert AB (Dec 2000). "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling". Trends Biochem Sci. 25 (10): 489–95. doi:10.1016/S0968-0004(00)01644-3. PMID 11050434.

[pmid11062263-6] Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151 (3): 627–38. doi:10.1083/jcb.151.3.627. PMC 2185579. PMID 11062263.

[entrez-7] "Entrez Gene: CENTB1 centaurin, beta 1".

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References

External links

Further reading