Bcl-2-interacting killer is a protein that in humans is encoded by the BIKgene.[5][6][7]
Function
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.[7]
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
^ abChen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell. 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID15694340.
Castells A, Ino Y, Louis DN, Ramesh V, Gusella JF, Rustgi AK (1999). "Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer". Gastroenterology. 117 (4): 831–7. doi:10.1016/S0016-5085(99)70341-0. PMID10500065.
Verma S, Budarf ML, Emanuel BS, Chinnadurai G (2000). "Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences". Gene. 254 (1–2): 157–62. doi:10.1016/S0378-1119(00)00276-6. PMID10974546.
Zou Y, Peng H, Zhou B, Wen Y, Wang SC, Tsai EM, Hung MC (2002). "Systemic tumor suppression by the proapoptotic gene bik". Cancer Res. 62 (1): 8–12. PMID11782349.
Arena V, Martini M, Luongo M, Capelli A, Larocca LM (2003). "Mutations of the BIK gene in human peripheral B-cell lymphomas". Genes Chromosomes Cancer. 38 (1): 91–6. doi:10.1002/gcc.10245. PMID12874789.