SUB1

SUB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PCF, 2C62, 2PHE, 4USG
Identifiers
Aliases	SUB1, P15, PC4, p14, SUB1 homolog, transcriptional regulator, SUB1 regulator of transcription
External IDs	OMIM: 600503; MGI: 104811; HomoloGene: 38218; GeneCards: SUB1; OMA:SUB1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	32,604,079 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	11,997,069 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; lactiferous duct; ; epithelium of colon; ; ganglionic eminence; ; gingival epithelium; ; parotid gland; ; bone marrow cells; ; germinal epithelium; ; endometrium; ; ventricular zone;
	Top expressed in
	genital tubercle; ; tail of embryo; ; yolk sac; ; abdominal wall; ; primitive streak; ; neural tube; ; gastrula; ; medial ganglionic eminence; ; migratory enteric neural crest cell; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	single-stranded DNA binding; DNA binding; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; RNA binding; identical protein binding; sequence-specific double-stranded DNA binding;
Cellular component	nucleolus; extracellular exosome; transcription regulator complex; nucleus;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription by RNA polymerase II; SMAD protein signal transduction; transcription, DNA-templated; positive regulation of transcription initiation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	10923
	20024
	ENSG00000113387
	ENSMUSG00000022205
	P53999
	P11031
	NM_006713
	NM_011294
	NP_006704
	NP_035424
	Wikidata
View/Edit Human	View/Edit Mouse

Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded by the SUB1 gene.^[5]^[6]^[7] The human SUB1 gene^[7] is named after an orthologous gene in yeast.^[8]

SUB1 is induced by oxidative stress, and is involved in coordinating cellular responses to DNA strand breaks that arise after oxidative stress^[9]. Yeast SUB1 has structural and functional similarities to human alpha-synuclein, a protein that has an important role in Parkinson’s disease.^[10] Like SUB1, alpha-synuclein functions in regulating DNA repair including repair of DNA double-strand breaks.

Interactions

SUB1 has been shown to interact with CSTF2.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113387 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022205 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kretzschmar M, Kaiser K, Lottspeich F, Meisterernst M (August 1994). "A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators". Cell. 78 (3): 525–34. doi:10.1016/0092-8674(94)90429-4. PMID 8062392.
^ Ge H, Roeder RG (August 1994). "Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes". Cell. 78 (3): 513–23. doi:10.1016/0092-8674(94)90428-6. PMID 8062391.
^ ^a ^b "Entrez Gene SUB1: SUB1 homolog (S. cerevisiae)".
^ Knaus R, Pollock R, Guarente L (April 1996). "Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4". The EMBO Journal. 15 (8): 1933–40. PMC 450112. PMID 8617240.
^ Yu L, Ma H, Ji X, Volkert MR. The Sub1 nuclear protein protects DNA from oxidative damage. Mol Cell Biochem. 2016 Jan;412(1-2):165-71. doi: 10.1007/s11010-015-2621-x. Epub 2015 Dec 26. PMID: 26708217
^ Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, Weston LJ, Owen N, Weissman TA, Luna E, Raber J, Luk KC, McCullough AK, Woltjer RL, Unni VK. Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. Sci Rep. 2019 Jul 29;9(1):10919. PMID: 31358782 PMCID:PMC6662836 DOI: 10.1038/s41598-019-47227-z
^ Calvo O, Manley JL (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Molecular Cell. 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. PMID 11389848.

External links

Overview of all the structural information available in the PDB for UniProt: P53999 (Activated RNA polymerase II transcriptional coactivator p15) at the PDBe-KB.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113387 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022205 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8062392-5] Kretzschmar M, Kaiser K, Lottspeich F, Meisterernst M (August 1994). "A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators". Cell. 78 (3): 525–34. doi:10.1016/0092-8674(94)90429-4. PMID 8062392.

[pmid8062391-6] Ge H, Roeder RG (August 1994). "Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes". Cell. 78 (3): 513–23. doi:10.1016/0092-8674(94)90428-6. PMID 8062391.

[entrez-7] "Entrez Gene SUB1: SUB1 homolog (S. cerevisiae)".

[pmid8617240-8] Knaus R, Pollock R, Guarente L (April 1996). "Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4". The EMBO Journal. 15 (8): 1933–40. PMC 450112. PMID 8617240.

[9] Yu L, Ma H, Ji X, Volkert MR. The Sub1 nuclear protein protects DNA from oxidative damage. Mol Cell Biochem. 2016 Jan;412(1-2):165-71. doi: 10.1007/s11010-015-2621-x. Epub 2015 Dec 26. PMID: 26708217

[10] Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, Weston LJ, Owen N, Weissman TA, Luna E, Raber J, Luk KC, McCullough AK, Woltjer RL, Unni VK. Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. Sci Rep. 2019 Jul 29;9(1):10919. PMID: 31358782 PMCID:PMC6662836 DOI: 10.1038/s41598-019-47227-z

[pmid11389848-11] Calvo O, Manley JL (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Molecular Cell. 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. PMID 11389848.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

Interactions

References

Further reading

External links