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Founder effect

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For the concept in organizations, see Founder's syndrome.
Founder effect: The original population (left) could give rise to different founder populations (right).

In population genetics, the founder effect is the loss of genetic variation that occurs when a new population is established by a very small number of individuals from a larger population. It was first fully outlined by Ernst Mayr in 1942,[1] using existing theoretical work by those such as Sewall Wright.[2] As a result of the loss of genetic variation, the new population may be distinctively different, both genotypically and phenotypically, from the parent population from which it is derived. In extreme cases, the founder effect is thought to lead to the speciation and subsequent evolution of new species.[3]

In the figure shown, the original population has nearly equal numbers of blue and red individuals. The three smaller founder populations show that one or the other color may predominate (founder effect), due to random sampling of the original population. A population bottleneck may also cause a founder effect, though it is not strictly a new population.

The founder effect occurs when a small group of migrants that is not genetically representative of the population from which they came establish in a new area.[4][5] In addition to founder effects, the new population is often a very small population, so shows increased sensitivity to genetic drift, an increase in inbreeding, and relatively low genetic variation.

Founder mutation

In genetics, a founder mutation is a mutation that appears in the DNA of one or more individuals which are founders of a distinct population. Founder mutations initiate with changes that occur in the DNA and can be passed down to other generations.[6][7] Any organism—from a simple virus to something complex like a mammal—whose progeny carry its mutation has the potential to express the founder effect[8], for instance a goat[9][10] or a human.[11]

Founder mutations originate in long stretches of DNA on a single chromosome; indeed, the original haplotype is the whole chromosome. As the generations progress, the proportion of the haplotype that is common to all carriers of the mutation is shortened (due to genetic recombination). This shortening allows scientists to roughly estimate the age of the mutation.[12]

General

The founder effect is a special case of genetic drift, occurring when a small group in a population splinters off from the original population and forms a new one. The new colony may have less genetic variation than the original population, and through the random sampling of alleles during reproduction of subsequent generations, continue rapidly towards fixation. This consequence of inbreeding makes the colony more vulnerable to extinction.[13]

When a newly formed colony is small, its founders can strongly affect the population's genetic makeup far into the future. In humans, who have a slow reproduction rate, the population will remain small for many generations, effectively amplifying the drift effect generation after generation until the population reaches a certain size. Alleles which were present but relatively rare in the original population can move to one of two extremes. The most common one is that the allele is soon lost altogether, but the other possibility is that the allele survives and within a few generations has become much more dispersed throughout the population. The new colony can experience an increase in the frequency of recessive alleles, as well, and as a result, an increased number who are homozygous for certain recessive traits.[citation needed]

The variation in gene frequency between the original population and colony may also trigger the two groups to diverge significantly over the course of many generations. As the variance, or genetic distance, increases, the two separated populations may become distinctively different, both genetically and phenotypically, although not only genetic drift, but also natural selection, gene flow and mutation all contribute to this divergence. This potential for relatively rapid changes in the colony's gene frequency led most scientists to consider the founder effect (and by extension, genetic drift) a significant driving force in the evolution of new species. Sewall Wright was the first to attach this significance to random drift and small, newly isolated populations with his shifting balance theory of speciation.[14] Following behind Wright, Ernst Mayr created many persuasive models to show that the decline in genetic variation and small population size accompanying the founder effect were critically important for new species to develop.[15] However, much less support for this view is shown today, since the hypothesis has been tested repeatedly through experimental research, and the results have been equivocal at best.[further explanation needed] Speciation by genetic drift is a specific case of peripatric speciation which in itself occurs in rare instances.[16] It takes place when a random change in genetic frequency of population favours the survival of a few organisms of the species with rare genes which cause reproductive mutation. These surviving organisms then breed among themselves over a long period of time to create a whole new species whose reproductive systems or behaviors are no longer compatible with the original population. [further explanation needed][17]

Serial founder effect

Serial founder effects have occurred when populations migrate over long distances. Such long-distance migrations typically involve relatively rapid movements followed by periods of settlement. The populations in each migration carry only a subset of the genetic diversity carried from previous migrations. As a result, genetic differentiation tends to increase with geographic distance as described by the "isolation by distance" model.[18] The migration of humans out of Africa is characterized by serial founder effects.[19] Africa has the highest degree of genetic diversity of any continent, which is consistent with an African origin of modern humans. After the initial migration from Africa, the Indian subcontinent was the first major settling point for modern humans. Consequently, India has the second-highest genetic diversity in the world. In general, the genetic diversity of the Indian subcontinent is a subset of Africa, and the genetic diversity outside Africa is a subset of India.[20][21]

In island ecology

Founder populations are essential to the study of island biogeography and island ecology. A natural "blank slate" is not easily found, but a classic series of studies on founder population effects was done following the catastrophic 1883 eruption of Krakatoa, which erased all life on the island. Another continuing study has been following the biocolonization of Surtsey, Iceland, a new volcanic island that erupted offshore between 1963 and 1967. An earlier event, the Toba eruption in Sumatra about 73,000 years ago, covered some parts of India with 3–6 m (10–20 ft) of ash, and must have coated the Nicobar Islands and Andaman Islands, much nearer in the ash fallout cone, with life-smothering layers, forcing the restart of their biodiversity.[citation needed]

However, not all founder effect studies are initiated after a natural disaster; some scientists study the reinstatement of a species that became locally extinct or hadn't existed there before. A study has been in place since 1958 studying the wolf/moose interaction on Isle Royale in Lake Superior after those animals naturally migrated there, perhaps on winter ice. Hajji and others, and Hundertmark & Van Daele, studied the current population statuses of past founder effects in Corsican red deer and Alaskan elk, respectively. Corsican red deer are still listed as an endangered species, decades after a severe bottleneck. They inhabit the Tyrrhenian islands and surrounding mainlands currently, and before the bottleneck, but Hajji and others wanted to know how the deer originally got to the islands, and from what parent population or species they were derived. Through molecular analysis, they were able to determine a possible lineage, with red deer from the islands of Corsica and Sardinia being the most related to one another. These results are promising, as the island of Corsica was repopulated with red deer from the Sardinian island after the original Corsican red deer population became extinct, and the deer now inhabiting the island of Corsica are diverging from those inhabiting Sardinia.[22][23]

Kolbe and others set up a pair of genetically sequenced and morphologically examined lizards on seven small islands to watch each new population's growth and adaptation to its new environment. Specifically, they were looking at the effects on limb length and perch width, both widely varying phenotypic ranges in the parent population. Unfortunately, immigration did occur, but the founder effect and adaptive differentiation, which could eventually lead to peripatric speciation, were statistically and biologically significant between the island populations after a few years. The authors also point out that although adaptive differentiation is significant, the differences between island populations best reflect the differences between founders and their genetic diversity that has been passed down through the generations.[24]

Founder effects can affect complex traits, such as song diversity. In the Common Myna (Acridotheres tristis), the percentage of unique songs within a repertoire and within‐song complexity were significantly lower in birds from founder populations.[25]

Among human populations

Due to various migrations throughout human history, founder effects are somewhat common among humans in different times and places. The French Canadians of Quebec are a classical example of founder population. Over 150 years of French colonization, between 1608 and 1760, an estimated 8,500 pioneers married and left at least one descendant on the territory.[26] Following the takeover of the colony by the British crown in 1760, immigration from France effectively stopped, but descendants of French settlers continued to grow in number mainly due to their high fertility rate. Intermarriage occurred mostly with the deported Acadians and migrants coming from the British Isles. Since the 20th century, immigration in Quebec and mixing of French Canadians involve people from all over the world. While the French Canadians of Quebec today may be partly of other ancestries, the genetic contribution of the original French founders is predominant, explaining about 90% of regional gene pools, while Acadians (descended from other French settlers in eastern Canada) explain[vague] 4% and British 2%, with Native American and other groups contributing less.[27][clarification needed]

In humans, founder effects can arise from cultural isolation, and inevitably, endogamy. For example, the Amish populations in the United States exhibit founder effects because they have grown from a very few founders, have not recruited newcomers, and tend to marry within the community. Though still rare, phenomena such as polydactyly (extra fingers and toes, a symptom of a condition such as[28][29] Weyers acrodental dysostosis[28] or Ellis-van Creveld syndrome[29]) are more common in Amish communities than in the American population at large.[30] Maple syrup urine disease affects about one out of 180,000 infants in the general population.[31] Due in part to the founder effect,[32] however, the disease has a much higher prevalence in children of Amish, Mennonite, and Jewish descent.[33][31][34] Similarly, a high frequency of fumarase deficiency exists among the 10,000 members of the Fundamentalist Church of Jesus Christ of Latter Day Saints, a community which practices both endogamy and polygyny, where an estimated 75-80% of the community are blood relatives of just two men—founders John Y. Barlow and Joseph Smith Jessop.[35] In South Asia, castes like the Gujjars, the Baniyas and the Pattapu Kapu have estimated founder effects about 10 times as strong as those of Finns and Ashkenazi Jews.[36]

The island of Pingelap also suffered a population bottleneck in 1775 following a typhoon that had reduced the population to only 20 people. As a result, today complete achromatopsia has a rate of occurrence of roughly 10%, with an additional 30% being carriers of this recessive condition.

Around 1814, a small group of British colonists founded a settlement on Tristan da Cunha, a group of small islands in the Atlantic Ocean, midway between Africa and South America. One of the early colonists apparently carried a rare, recessive allele for retinitis pigmentosa, a progressive form of blindness that afflicts homozygous individuals. As late as 1961, the majority of the genes in the gene pool on Tristan were still derived from 15 original ancestors; as a consequence of the inbreeding, of 232 people tested in 1961, four were suffering from retinitis pigmentosa. This represents a prevalence of 1 in 58, compared with a worldwide prevalence of around 1 in 4,000.[37]

The abnormally high rate of twin births in Cândido Godói could be explained by the founder effect.[38]

See also

References

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  4. ^ Hartwell, Leland; Hood, Leroy; Goldberg, Michael; Reynolds, Ann E.; Silver, Lee; Veres, Ruth C (2004). Genetics: From Genes to Genomes. p. 241. ISBN 978-0-07-121468-1.
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  8. ^ Joseph, S. B.; Swanstrom, R.; Kashuba, A. D.; Cohen, M. S. (2015). "Bottlenecks in HIV-1 transmission: insights from the study of founder viruses". Nature Reviews Microbiology. 13 (7): 414–425. doi:10.1038/nrmicro3471. PMC 4793885. PMID 26052661.
  9. ^ Cooper, C. A.; Garas Klobas, L. C.; Maga, E. A.; Murray, J. D. (2013). "Consuming transgenic goats' milk containing the antimicrobial protein lysozyme helps resolve diarrhea in young pigs". PLOS ONE. 8 (3): e58409. Bibcode:2013PLoSO...858409C. doi:10.1371/journal.pone.0058409. PMC 3596375. PMID 23516474.{{cite journal}}: CS1 maint: unflagged free DOI (link)
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  12. ^ Drayna, Dennis (2005). "Founder Mutations: Scientific American". Scientific American. 293 (4): 78–85. doi:10.1038/scientificamerican1005-78. PMID 16196257.
  13. ^ Reece, Jane B. (2011). Campbell biology, AP edition (9th ed.). Boston, MA: Pearson Education/Benjamin Cummings. ISBN 978-0-13-137504-8. OCLC 792861278.
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  15. ^ Mayr, Ernst; Hey, Jody; Fitch, Walter M.; Ayala, Francisco José (2005). Systematics and the Origin of Species: on Ernst Mayr's 100th anniversary (Illustrated ed.). National Academies Press. p. 367. ISBN 978-0-309-09536-5.
  16. ^ "Peripatric Speciation". evolution.berkeley.edu. Archived from the original on April 23, 2004.
  17. ^ Howard, Daniel J.; Berlocher, Steward H. (1998). Endless Forms (Illustrated ed.). United States: Oxford University Press. p. 470. ISBN 978-0-19-510901-6.
  18. ^ Ramachandran, S.; Deshpande, O.; Roseman, C. C.; Rosenberg, N. A.; Feldman, M. W.; Cavalli-Sforza, L. L. (2005). "Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa". Proceedings of the National Academy of Sciences. 102 (44): 15942–7. Bibcode:2005PNAS..10215942R. doi:10.1073/pnas.0507611102. JSTOR 4143304. PMC 1276087. PMID 16243969.
  19. ^ Degiorgio, M.; Jakobsson, M.; Rosenberg, N. A. (2009). "Explaining worldwide patterns of human genetic variation using a coalescent-based serial founder model of migration outward from Africa". Proceedings of the National Academy of Sciences. 106 (38): 16057–62. Bibcode:2009PNAS..10616057D. doi:10.1073/pnas.0903341106. JSTOR 40485019. PMC 2752555. PMID 19706453.
  20. ^ Maji, Suvendu; Krithika, S.; Vasulu, T. S. (2009). "Phylogeographic distribution of mitochondrial DNA macrohaplogroup M in India". Journal of Genetics. 88 (1): 127–39. doi:10.1007/s12041-009-0020-3. PMID 19417557.
  21. ^ Thangaraj, Kumarasamy; Chaubey, Gyaneshwer; Singh, Vijay; Vanniarajan, Ayyasamy; Thanseem, Ismail; Reddy, Alla G.; Singh, Lalji (2006). "In situ origin of deep rooting lineages of mitochondrial Macrohaplogroup 'M' in India". BMC Genomics. 7: 151. doi:10.1186/1471-2164-7-151. PMC 1534032. PMID 16776823.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  22. ^ Hajji, Ghaiet M.; Charfi-Cheikrouha, F.; Lorenzini, Rita; Vigne, Jean-Denis; Hartl, Günther B.; Zachos, Frank E. (2007). "Phylogeography and founder effect of the endangered Corsican red deer (Cervus elaphus corsicanus)". Biodiversity and Conservation. 17 (3): 659–73. doi:10.1007/s10531-007-9297-9.
  23. ^ Hundertmark, Kris J.; Van Daele, Larry J. (2009). "Founder effect and bottleneck signatures in an introduced, insular population of elk". Conservation Genetics. 11: 139–47. doi:10.1007/s10592-009-0013-z.
  24. ^ Kolbe, J. J.; Leal, M.; Schoener, T. W.; Spiller, D. A.; Losos, J. B. (2012). "Founder Effects Persist Despite Adaptive Differentiation: A Field Experiment with Lizards". Science. 335 (6072): 1086–9. Bibcode:2012Sci...335.1086K. CiteSeerX 10.1.1.363.77. doi:10.1126/science.1209566. PMID 22300849.
  25. ^ Hill, Samuel D.; Pawley, Matthew D. M. (2019). "Reduced song complexity in founder populations of a widely distributed songbird". Ibis. 161 (2): 435–440. doi:10.1111/ibi.12692. ISSN 1474-919X.
  26. ^ Charbonneau, Hubert; Desjardins, Bertrand; Légaré, Jacques; Denis, Hubert (2010). "The Population of the St. Lawrence Valley 1608–1760". In Haines, Michael R.; Stecke, Richard H. (eds.). A Population History of North America. pp. 99–142. ISBN 978-0-521-49666-7. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help)
  27. ^ Bherer, Claude; Labuda, Damian; Roy-Gagnon, Marie-Hélène; Houde, Louis; Tremblay, Marc; Vézina, Hélène (2011). "Admixed ancestry and stratification of Quebec regional populations". American Journal of Physical Anthropology. 144 (3): 432–41. doi:10.1002/ajpa.21424. PMID 21302269.
  28. ^ a b "Weyers acrofacial dysostosis / "Genetics Home Reference" ("Your Guide to Understanding Genetic Conditions"), from the "US National Library of Medicine"". National Library of Medicine (NLM), which is part of the National Institutes of Health, an agency of the U.S. Department of Health and Human Services ... ((Note: archived from an earlier version of the original.)). July 18, 2017. Archived from the original on June 27, 2017. Retrieved July 24, 2017. People with Weyers acrofacial dysostosis have abnormally small or malformed fingernails and toenails. Most people with the condition are relatively short, and they may have extra fingers or toes (polydactyly). [...] The features of Weyers acrofacial dysostosis overlap with those of another, more severe condition called Ellis-van Creveld syndrome. In addition to tooth and nail abnormalities, people with Ellis-van Creveld syndrome have very short stature and are often born with heart defects. The two conditions are caused by mutations in the same genes.
  29. ^ a b "How are genetic conditions and genes named? / "Genetics Home Reference" ("Your Guide to Understanding Genetic Conditions"), from the "US National Library of Medicine"". National Library of Medicine (NLM), which is part of the National Institutes of Health, an agency of the U.S. Department of Health and Human Services ... ((Note: archived from an earlier version of the original.)). July 18, 2017. Archived from the original on July 9, 2017. Retrieved July 24, 2017.
  30. ^ McKusick, V. A.; Egeland, J. A.; Eldridge, R; Krusen, D. E. (1964). "Dwarfism in the Amish I. The Ellis-Van Creveld Syndrome". Bulletin of the Johns Hopkins Hospital. 115: 306–36. PMID 14217223.
  31. ^ a b http://rarediseases.about.com/od/rarediseases1/a/062004.htm
    About.com: Rare diseases - June 2004. Maple syrup urine disease by Mary Kugler, R.N.
    Article describes MSUD prevalence among Amish and Mennonite children.
  32. ^ Jaworski, M. A.; Severini, A; Mansour, G; Konrad, H. M.; Slater, J; Hennig, K; Schlaut, J; Yoon, J. W.; Pak, C. Y.; MacLaren, N (1989). "Genetic conditions among Canadian Mennonites: Evidence for a founder effect among the old colony (Chortitza) Mennonites". Clinical and Investigative Medicine. Medecine Clinique et Experimentale. 12 (2): 127–41. PMID 2706837.
  33. ^ Puffenberger, E.G. (2003). "Genetic heritage of the Old Order Mennonites of southeastern Pennsylvania". American Journal of Medical Genetics. 121C (1): 18–31. doi:10.1002/ajmg.c.20003. PMID 12888983.
  34. ^ "Maple Syrup Urine Disease (MSUD) - Jewish Genetic Disease".
  35. ^ Forbidden Fruit:Inbreeding among polygamists along the Arizona-Utah border is producing a caste of severely retarded and deformed children, by John Dougherty, The Phoenix New Times News, December 29, 2005, page 2.
  36. ^ Yin, Steph (2017-07-17). "In South Asian Social Castes, a Living Lab for Genetic Disease". The New York Times. ISSN 0362-4331. Retrieved 2020-03-13.
  37. ^ Berry, RJ (1967). "Genetical changes in mice and men". Eugen Rev. 59 (2): 78–96. PMC 2906351. PMID 4864588.
  38. ^ De Oliveira, Marcelo Zagonel; Schüler-Faccini, Lavínia; Demarchi, Dario A.; Alfaro, Emma L.; Dipierri, José E.; Veronez, Mauricio R.; Colling Cassel, Marlise; Tagliani-Ribeiro, Alice; Silveira Matte, Ursula; Ramallo, Virginia (2013). "So Close, So Far Away: Analysis of Surnames in a Town of Twins (Cândido Godói, Brazil)". Annals of Human Genetics. 77 (2): 125–36. doi:10.1111/ahg.12001. PMID 23369099.

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