Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6gene.[5][6][7]
Function
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yi J, Beckerle MC (Apr 1998). "The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis". Genomics. 49 (2): 314–6. doi:10.1006/geno.1998.5248. PMID9598321.
^Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID7776974.
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Further reading
Williams JM, Chen GC, Zhu L, Rest RF (Jan 1998). "Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth". Molecular Microbiology. 27 (1): 171–86. doi:10.1046/j.1365-2958.1998.00670.x. PMID9466265.
Cuppen E, van Ham M, Wansink DG, de Leeuw A, Wieringa B, Hendriks W (Apr 2000). "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL". European Journal of Cell Biology. 79 (4): 283–93. doi:10.1078/S0171-9335(04)70031-X. PMID10826496.
Petit MM, Crombez KR, Vervenne HB, Weyns N, Van de Ven WJ (Sep 2005). "The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins". FEBS Letters. 579 (22): 5061–8. doi:10.1016/j.febslet.2005.08.012. PMID16137684.
External links
Overview of all the structural information available in the PDB for UniProt: Q15654 (Thyroid receptor-interacting protein 6) at the PDBe-KB.