Sperm-associated antigen 8

SPAG8
Identifiers
Aliases	SPAG8, BS-84, CILD28, CT142, HSD-1, SMP1, SPAG3, hSMP-1, sperm associated antigen 8
External IDs	OMIM: 605731; MGI: 3056295; HomoloGene: 8250; GeneCards: SPAG8; OMA:SPAG8 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	35,812,272 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	43,653,594 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; tendon of biceps brachii; ; olfactory zone of nasal mucosa; ; left testis; ; right testis; ; bronchial epithelial cell; ; mucosa of paranasal sinus; ; Epithelium of choroid plexus; ; anterior pituitary; ; buccal mucosa cell;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; embryo; ; embryo; ; otolith organ; ; utricle; ; olfactory epithelium; ; right lung lobe; ; Epithelium of choroid plexus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; molecular function; microtubule binding;
Cellular component	acrosomal vesicle; membrane; cytoplasmic vesicle; cytoskeleton; cytoplasm; nucleus; spindle;
Biological process	single fertilization; cell differentiation; spermatogenesis; cell cycle; biological process; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	26206
	433700
	ENSG00000137098
	ENSMUSG00000066196
	Q99932
	Q3V0Q6
	NM_001039592; NM_012436; NM_172312
	NM_001007463; NM_001290462
	NP_001034681; NP_758516; NP_001353689
	NP_001007464; NP_001277391
	Wikidata
View/Edit Human	View/Edit Mouse

Sperm-associated antigen 8 is a protein that in humans is encoded by the SPAG8 gene.^[5]^[6]^[7]

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137098 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066196 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang H, Miao S, Chen D, Wang L, Koide SS (Nov 1999). "Assignment of chromosomal locus and evidence for alternatively spliced mRNAs of a human sperm membrane protein (hSMP-1)". Biochim Biophys Acta. 1447 (1): 119–24. doi:10.1016/s0167-4781(99)00136-0. PMID 10500252.
^ Liu QY, Wang LF, Miao SY, Catterall JF (Oct 1996). "Expression and characterization of a novel human sperm membrane protein". Biol Reprod. 54 (2): 323–30. doi:10.1095/biolreprod54.2.323. PMID 8788182.
^ ^a ^b "Entrez Gene: SPAG8 sperm associated antigen 8".

Diekman AB, Herr JC (1997). "Sperm antigens and their use in the development of an immunocontraceptive". Am. J. Reprod. Immunol. 37 (1): 111–7. doi:10.1111/j.1600-0897.1997.tb00199.x. PMID 9138444.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Kuang Y, Yan YC, Gao AW, et al. (2001). "Immune responses in rats following oral immunization with attenuated Salmonella typhimurium expressing human sperm antigen". Arch. Androl. 45 (3): 169–80. doi:10.1080/01485010050193940. PMID 11111865.
Zhang XD, Miao SY, Wang LF, et al. (2001). "Human sperm membrane protein (hSMP-1): a developmental testis-specific component during germ cell differentiation". Arch. Androl. 45 (3): 239–46. doi:10.1080/01485010050194020. PMID 11111873.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tang X, Zhang J, Cai Y, et al. (2004). "Sperm membrane protein (hSMP-1) and RanBPM complex in the microtubule-organizing centre". J. Mol. Med. 82 (6): 383–8. doi:10.1007/s00109-004-0535-2. PMID 15014887.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cheng GY, Shi JL, Wang M, et al. (2007). "Inhibition of mouse acrosome reaction and sperm-zona pellucida binding by anti-human sperm membrane protein 1 antibody". Asian J. Androl. 9 (1): 23–9. doi:10.1111/j.1745-7262.2007.00247.x. PMID 17187156.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137098 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066196 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10500252-5] Wang H, Miao S, Chen D, Wang L, Koide SS (Nov 1999). "Assignment of chromosomal locus and evidence for alternatively spliced mRNAs of a human sperm membrane protein (hSMP-1)". Biochim Biophys Acta. 1447 (1): 119–24. doi:10.1016/s0167-4781(99)00136-0. PMID 10500252.

[pmid8788182-6] Liu QY, Wang LF, Miao SY, Catterall JF (Oct 1996). "Expression and characterization of a novel human sperm membrane protein". Biol Reprod. 54 (2): 323–30. doi:10.1095/biolreprod54.2.323. PMID 8788182.

[entrez-7] "Entrez Gene: SPAG8 sperm associated antigen 8".

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References

Further reading