RREB1

RREB1
Identifiers
Aliases	RREB1, FINB, HNT, LZ321, RREB-1, Zep-1, ras responsive element binding protein 1
External IDs	OMIM: 602209; MGI: 2443664; HomoloGene: 2218; GeneCards: RREB1; OMA:RREB1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	7,251,980 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	38,135,981 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; epithelium of nasopharynx; ; oral cavity; ; skin of thigh; ; sural nerve; ; mucosa of pharynx; ; parotid gland; ; skin of hip; ; epithelium of esophagus; ; mucosa of sigmoid colon;
	Top expressed in
	left lung lobe; ; substantia nigra; ; pineal gland; ; ciliary body; ; lacrimal gland; ; Paneth cell; ; migratory enteric neural crest cell; ; conjunctival fornix; ; anterior amygdaloid area; ; olfactory tubercle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; metal ion binding; nucleic acid binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nuclear body; extracellular exosome; fibrillar center; nucleus; cytoplasm; nuclear speck;
Biological process	positive regulation of mammary gland epithelial cell proliferation; positive regulation of lamellipodium morphogenesis; regulation of transcription, DNA-templated; positive regulation of epithelial cell migration; transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; positive regulation of transcription, DNA-templated; positive regulation of substrate adhesion-dependent cell spreading; Ras protein signal transduction; negative regulation of transcription, DNA-templated; positive regulation of wound healing, spreading of epidermal cells; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6239
	68750
	ENSG00000124782
	ENSMUSG00000039087
	Q92766
	Q3UH06
	NM_001003698; NM_001003699; NM_001003700; NM_001168344; NM_002955
	NM_001013392; NM_001039188; NM_001177868; NM_001177869; NM_026830
NP_001003698; NP_001003699; NP_001003700; NP_001161816; NP_001003698.1;
	NP_001161816.1
NP_001034277; NP_001171339; NP_001171340; NP_081106; NP_001391686;
	NP_001391687; NP_001391688; NP_001391689
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.^[5]^[6]^[7]

Clinical significance

Mutations in RREB1 are associated to type 2 diabetes associated end-stage kidney disease.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124782 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039087 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD (Jan 1998). "RREB1, a ras responsive element binding protein, maps to human chromosome 6p25". Genomics. 45 (3): 630–632. doi:10.1006/geno.1997.5001. PMID 9367691.
^ Melani M, Simpson KJ, Brugge JS, Montell D (Apr 2008). "Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1". Curr Biol. 18 (7): 532–537. doi:10.1016/j.cub.2008.03.024. PMID 18394891.
^ "Entrez Gene: RREB1 ras responsive element binding protein 1".
^ Bonomo, J. A.; Guan, M; Ng, M. C.; Palmer, N. D.; Hicks, P. J.; Keaton, J. M.; Lea, J. P.; Langefeld, C. D.; Freedman, B. I.; Bowden, D. W. (2014). "The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease". Human Molecular Genetics. 23 (24): 6441–7. doi:10.1093/hmg/ddu362. PMC 4240197. PMID 25027322.

Thiagalingam A; De Bustros A; Borges M; et al. (1996). "RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas". Mol. Cell. Biol. 16 (10): 5335–45. doi:10.1128/mcb.16.10.5335. PMC 231532. PMID 8816445. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Fujimoto-Nishiyama A; Ishii S; Matsuda S; et al. (1997). "A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies". Gene. 195 (2): 267–275. doi:10.1016/S0378-1119(97)00172-8. PMID 9305772. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Zhang L, Zhao J, Edenberg HJ (1999). "A human Raf-responsive zinc-finger protein that binds to divergent sequences". Nucleic Acids Res. 27 (14): 2947–2956. doi:10.1093/nar/27.14.2947. PMC 148511. PMID 10390538.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ray SK; Nishitani J; Petry MW; et al. (2003). "Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1". Mol. Cell. Biol. 23 (1): 259–271. doi:10.1128/MCB.23.1.259-271.2003. PMC 140679. PMID 12482979. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Zhang S; Qian X; Redman C; et al. (2003). "p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB". Oncogene. 22 (15): 2285–2295. doi:10.1038/sj.onc.1206257. PMID 12700664. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Shi Y; Sawada J; Sui G; et al. (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–738. Bibcode:2003Natur.422..735S. doi:10.1038/nature01550. PMID 12700765. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Date S; Nibu Y; Yanai K; et al. (2005). "Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene". Int. J. Mol. Med. 13 (5): 637–42. doi:10.3892/ijmm.13.5.637. PMID 15067362. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Beausoleil SA; Jedrychowski M; Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124782 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039087 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9367691-5] Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD (Jan 1998). "RREB1, a ras responsive element binding protein, maps to human chromosome 6p25". Genomics. 45 (3): 630–632. doi:10.1006/geno.1997.5001. PMID 9367691.

[pmid18394891-6] Melani M, Simpson KJ, Brugge JS, Montell D (Apr 2008). "Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1". Curr Biol. 18 (7): 532–537. doi:10.1016/j.cub.2008.03.024. PMID 18394891.

[entrez-7] "Entrez Gene: RREB1 ras responsive element binding protein 1".

[8] Bonomo, J. A.; Guan, M; Ng, M. C.; Palmer, N. D.; Hicks, P. J.; Keaton, J. M.; Lea, J. P.; Langefeld, C. D.; Freedman, B. I.; Bowden, D. W. (2014). "The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease". Human Molecular Genetics. 23 (24): 6441–7. doi:10.1093/hmg/ddu362. PMC 4240197. PMID 25027322.

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Clinical significance

References

Further reading