The music video for "Mujeres in the Club" was directed by Jessy Terrero, Wisin & Yandel's long-time working music video director. It was released by Universal Music Group on April 17, 2009 on YouTube and premiered on MTV Tr3s on April 14, 2009. The video is set in 2050 when the world has destroyed itself and features 50 Cent and a cameo by Julissa Bermudez. To date the video has received over 4,900,000 views through its posting by UMG.[1]