Lusutrombopag

Lusutrombopag
Clinical data
Trade names	Mulpleta, Mulpleo
AHFS/Drugs.com	Monograph
License data	EU EMA: by INN; US DailyMed: Lusutrombopag;
Routes of; administration	By mouth
ATC code	B02BX07 (WHO) ;
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Identifiers
	IUPAC name (E)-3-[2,6-Dichloro-4-[[4-[3-[(1S)-1-hexoxyethyl]-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid;
CAS Number	1110766-97-6 ;
PubChem CID	49843517;
DrugBank	DB13125 ;
ChemSpider	21106301 ;
UNII	S56D65XJ9G;
KEGG	D10476;
ChEMBL	ChEMBL461101 ;
CompTox Dashboard (EPA)	DTXSID701027951 ;
Chemical and physical data
Formula	C29H32Cl2N2O5S
Molar mass	591.54 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCCOC(C)C1=CC=CC(=C1OC)C2=CSC(=N2)NC(=O)C3=CC(=C(C(=C3)Cl)C=C(C)C(=O)O)Cl;
	InChI InChI=1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1 ; Key:NOZIJMHMKORZBA-KJCUYJGMSA-N ;
	(what is this?)

Lusutrombopag is a medication that has been developed for certain conditions that lead to thrombocytopenia (abnormally low platelet counts) such as thrombocytopenia associated with chronic liver disease in patients prior to elective invasive procedures. It is being manufactured and marketed in Japan by Shionogi under the trade name Mulpleta.^[1]^[2]^[3] It was approved by the FDA in July 2018 and NICE in January 2020.^[4]^[5]

It was approved for medical use in the European Union in February 2019.^[6]

References

^ Shionogi Receives Marketing and Manufacturing Approval in Japan for MULPLETA® Tablets 3mg for Improvement of Thrombocytopenia, September 28, 2015
^ Shionogi Launches MULPLETA® Tablets 3mg In Japan for Improvement of Thrombocytopenia
^ Lusutrombopag (MULPLETA) for severe thrombocytopenia in patients with chronic liver disease undergoing an elective invasive procedure
^ "FDA approves lusutrombopag for thrombocytopenia in adults with chronic liver disease". Food and Drug Administration. July 31, 2018.
^ https://www.nice.org.uk/guidance/ta617
^ "Mulpleo EPAR". European Medicines Agency (EMA). Retrieved 17 June 2020.

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[1] Shionogi Receives Marketing and Manufacturing Approval in Japan for MULPLETA® Tablets 3mg for Improvement of Thrombocytopenia, September 28, 2015

[2] Shionogi Launches MULPLETA® Tablets 3mg In Japan for Improvement of Thrombocytopenia

[3] Lusutrombopag (MULPLETA) for severe thrombocytopenia in patients with chronic liver disease undergoing an elective invasive procedure

[4] "FDA approves lusutrombopag for thrombocytopenia in adults with chronic liver disease". Food and Drug Administration. July 31, 2018.

[5] ttps://www.nice.org.uk/guidance/ta617

[6] "Mulpleo EPAR". European Medicines Agency (EMA). Retrieved 17 June 2020.

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