From Wikipedia, the free encyclopedia
Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene .[ 5] [ 6]
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[ 6]
Interactions
GRB14 has been shown to interact with Epidermal growth factor receptor ,[ 7] Fibroblast growth factor receptor 1 [ 8] and TNKS2 .[ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000115290 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026888 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Baker E, Sutherland GR, Sutherland RL, Daly RJ (February 1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics . 36 (1): 218–220. doi :10.1006/geno.1996.0453 . PMID 8812444 .
^ a b "Entrez Gene: GRB14 growth factor receptor-bound protein 14" .
^ Daly, R J; Sanderson G M; Janes P W; Sutherland R L (May 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family" . J. Biol. Chem . 271 (21). UNITED STATES: 12502–12510. doi :10.1074/jbc.271.21.12502 . ISSN 0021-9258 . PMID 8647858 .
^ Reilly, J F; Mickey G; Maher P A (March 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner" . J. Biol. Chem . 275 (11). UNITED STATES: 7771–7778. doi :10.1074/jbc.275.11.7771 . ISSN 0021-9258 . PMID 10713090 .
^ Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14" . J. Biol. Chem . 276 (20). United States: 17172–17180. doi :10.1074/jbc.M009756200 . ISSN 0021-9258 . PMID 11278563 .
Further reading
Han DC, Shen TL, Guan JL (2001). "The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions" . Oncogene . 20 (44): 6315–6321. doi :10.1038/sj.onc.1204775 . PMID 11607834 .
Daly RJ, Sanderson GM, Janes PW, Sutherland RL (1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family" . J. Biol. Chem . 271 (21): 12502–12510. doi :10.1074/jbc.271.21.12502 . PMID 8647858 .
Kasus-Jacobi A; Perdereau D; Auzan C; et al. (1998). "Identification of the rat adapter Grb14 as an inhibitor of insulin actions" . J. Biol. Chem . 273 (40): 26026–26035. doi :10.1074/jbc.273.40.26026 . PMID 9748281 .
Jones N; Master Z; Jones J; et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration" . J. Biol. Chem . 274 (43): 30896–30905. doi :10.1074/jbc.274.43.30896 . PMID 10521483 .
Reilly JF, Mickey G, Maher PA (2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner" . J. Biol. Chem . 275 (11): 7771–7778. doi :10.1074/jbc.275.11.7771 . PMID 10713090 .
Hemming R; Agatep R; Badiani K; et al. (2001). "Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins". Biochem. Cell Biol . 79 (1): 21–32. doi :10.1139/bcb-79-1-21 . PMID 11235915 .
Lyons RJ; Deane R; Lynch DK; et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14" . J. Biol. Chem . 276 (20): 17172–17180. doi :10.1074/jbc.M009756200 . PMID 11278563 .
Béréziat V; Kasus-Jacobi A; Perdereau D; et al. (2002). "Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14" . J. Biol. Chem . 277 (7): 4845–4852. doi :10.1074/jbc.M106574200 . PMID 11726652 .
Cariou B; Perdereau D; Cailliau K; et al. (2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta" . Mol. Cell. Biol . 22 (20): 6959–6970. doi :10.1128/MCB.22.20.6959-6970.2002 . PMC 139806 . PMID 12242277 .
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
King CC, Newton AC (2004). "The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1" . J. Biol. Chem . 279 (36): 37518–37527. doi :10.1074/jbc.M405340200 . PMID 15210700 .
Scharf PJ, Witney J, Daly R, Lyons BA (2005). "Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain" . Protein Sci . 13 (9): 2541–2546. doi :10.1110/ps.04884704 . PMC 2280013 . PMID 15322292 .
Kairouz R; Parmar J; Lyons RJ; et al. (2005). "Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells". J. Cell. Physiol . 203 (1): 85–93. doi :10.1002/jcp.20199 . PMID 15372466 .
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Depetris RS; Hu J; Gimpelevich I; et al. (2006). "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14" . Mol. Cell . 20 (2): 325–333. doi :10.1016/j.molcel.2005.09.001 . PMC 4526137 . PMID 16246733 .
Park JJ; Berggren JR; Hulver MW; et al. (2006). "GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle". Physiol. Genomics . 27 (2): 114–121. doi :10.1152/physiolgenomics.00045.2006 . PMID 16849634 .