Saccharopolyspora erythraea
| Saccharopolyspora erythraea | |
|---|---|
| |
| Scientific classification | |
| Kingdom: | |
| Phylum: | |
| Class: | Actinobacteria
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| Subclass: | |
| Order: | |
| Family: | |
| Genus: | |
| Species: | S. erythraea
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| Binomial name | |
| Saccharopolyspora erythraea | |
| Synonyms | |
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Saccharopolyspora erythrea (lapsus) | |
Saccharopolyspora erythraea, formerly known as Streptomyces erythraeus,[1] is a species of actinomycete bacteria within the genus Saccharopolyspora.
Saccharopolyspora erythraea produces the macrolide antibiotic erythromycin.[2] Cytochrome P450 eryF (CYP107A1) originally from the bacterium is responsible for the biosynthesis of the antibiotic by C6-hydroxylation of the macrolide 6-deoxyerythronolide B.[3][4]
Small non-coding RNAs have been suggested to be involved in regulation of the secondary metabolite biosynthesis.[5]
References
- ^ "Transfer of the Type Strain of Streptomyces erythraeus (Waksman 1923) Waksman and Henrici 1948 to the Genus Saccharopolyspora Lacey and Goodfellow 1975 as Saccharopolyspora erythraea sp. nov., and Designation of a Neotype Strain for Streptomyces erythraeus -- Labeda 37 (1): 19 -- International Journal of Systematic Bacteriology".
- ^ Oliynyk, Markiyan; Samborskyy, Markiyan; Lester, John B.; Mironenko, Tatiana; Scott, Nataliya; Dickens, Shilo; Haydock, Stephen F.; Leadlay, Peter F. (2007). "Complete genome sequence of the erythromycin-producing bacterium : Saccharopolyspora erythraea: NRRL23338". Nature Biotechnology. 25 (4): 447–453. doi:10.1038/nbt1297. PMID 17369815.
- ^ Cupp-Vickery, JR; Poulos, TL (February 1995). "Structure of cytochrome P450eryF involved in erythromycin biosynthesis". Nature Structural Biology. 2 (2): 144–53. doi:10.1038/nsb0295-144. PMID 7749919.
- ^ Harris, DL (20 September 2002). "Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450eryF". Journal of Inorganic Biochemistry. 91 (4): 568–85. doi:10.1016/s0162-0134(02)00477-4. PMID 12237223.
- ^ Liu, Wei-Bing; Shi, Yang; Yao, Li-Li; Zhou, Ying; Ye, Bang-Ce (2013-01-01). "Prediction and characterization of small non-coding RNAs related to secondary metabolites in Saccharopolyspora erythraea". PLOS ONE. 8 (11): e80676. Bibcode:2013PLoSO...880676L. doi:10.1371/journal.pone.0080676. ISSN 1932-6203. PMC 3827479. PMID 24236194.
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External links
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