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Qasim Mehdi

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S. Qasim Mehdi
Born13 February 1941
Died28 September 2016 (aged 75)
NationalityPakistan
CitizenshipPakistan
Alma mater
Known for
Awards
Hilal-e-Imtiaz

Sitara-e-Imtiaz

Scientific career
FieldsMolecular biology, Genetics
Institutions

Biomedical & Genetic Engineering Division, Pakistan

ThesisSynthesis and Control of Bacterial Ribonucleic Acids (1969)

S. Qasim Mehdi (or Syed Qasim Mehdi) was a renowned Pakistani molecular biologist[1][2][3] who worked in Population genetics. He was a founding member of the Human Genome Diversity Project (HGDP) with prominent role in the initiation of this project at the Stanford University.[4]

Biography

Mehdi was born in Lucknow, India, where he completed his B.S. from the Lucknow University. He received his MS from MIT and then a D. Phil. (Doctorate) degree from the Oxford University, where he had mentors like Nobel laureates Sir Hans Krebs and Rodney Porter. His doctoral education was followed by a series of fellowships at the Oxford and the Wellcome Trust, till appointed by the Stanford University as a research associate in 1976 and later a senior research fellow, affiliated with the Stanford University Departments of Chemistry and Radiology and Stanford Cancer Biology Research Labs.[3] He has been fellow of the Wellcome Trust (1972-1974) and the Biochemical Society, UK (1972-1997), other than holding numerous other honors, awards, and fellowships.

His last appointment was serving as the chairman of the Center for Human Genetics at the Sindh Institute of Urology and Transplantation, Karachi, Pakistan, as well as a Distinguished Visiting Professor in the University of Karachi, Karachi Pakistan.[5] In past, he had served as a Distinguished National Professor, Higher Education Commission Pakistan, and Director General of the Biomedical & Genetic Engineering Division, Islamabad,[2] at the Institute for Biotechnology & Genetic Engineering, University of Karachi, Pakistan. He was a recipient of the Government of Pakistan civil awards, Sitara-e-Imtiaz (1998) and Hilal-e-Imtiaz, the "Crescent of Distinction" (2003) conferred by the President of Pakistan.

He had been a member of the American Association for the Advancement of Science, the New York Academy of Sciences, Prime Ministers Cabinet Committee for the Evaluation of Research, Development in Science and Technology in Pakistan, Advanced Studies Board, HEJ Research Inst. of Chemistry, Karachi University, 1993-, The World Bank Committee for Higher Education in Pakistan, elected member, Scientific and Medical Advisory Board, the International Retinitis Pigmentosa Society (Retinitis Pigmentosa International) and The Foundation Fighting Blindness society, Washington DC (1993–present), Human Genome Organization (HUGO), London (UK), Founding Member, Human Genome Diversity Project (HGDP) USA. (1994–present), chairman, Southwest Asia Committee and Member International Executive Committee, HGDP and (1997–present), among a number of other professional bodies.

During his last years, he had been working on charting a direction for the future of biomedical research in Pakistan.[6]

Other than his role in HGDP, he is known for his groundbreaking work on the genetics of human populations,[2] especially on research work related to the human features of Light skin and Dark skin, where he and his team made important contributions (ref.: see Light skin and Dark skin pages citing his work). He has written over two hundred publications, including papers in Science, Nature Genetics and Genome Research. As per google scholar, his publications have accrued a total number of 7745 citations, his scholarly indices include an h-index of 38 and I10-index of 67.[7]

Mehdi passed away peacefully in Lahore on 28 September 2016 after a protracted illness.[8]

Fellowships

Fellow Wellcome Trust

Fellow Biochemical Society

Fellow Third World Academy of Sciences

Fellow Pakistan Academy of Sciences

Fellow Islamic Academy of Sciences

Fellow Chemical Society of Pakistan

Selected publications (highly-cited work)

  • Underhill, Peter A.; Shen, Peidong; Lin, Alice A.; Jin, Li; Passarino, Giuseppe; Yang, Wei H.; Kauffman, Erin; Bonné-Tamir, Batsheva; Bertranpetit, Jaume; Francalacci, Paolo; others (1 January 2000). "Y chromosome sequence variation and the history of human populations". Nature Genetics. 26 (3): 358–361. doi:10.1038/81685. PMID 11062480.
  • Underhill, Peter A.; Jin, Li; Lin, Alice A.; Mehdi, S. Qasim; Jenkins, Trefor; Vollrath, Douglas; Davis, Ronald W.; Cavalli-Sforza, L. Luca; Oefner, Peter J. (1 January 1997). "Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography". Genome Research. 7 (10): 996–1005. doi:10.1101/gr.7.10.996. PMC 310671. PMID 9331370.
  • Cann, Howard M.; De Toma, Claudia; Cazes, Lucien; Legrand, Marie-Fernande; Morel, Valerie; Piouffre, Laurence; Bodmer, Julia; Bodmer, Walter F.; Bonne-Tamir, Batsheva; Cambon-Thomsen, Anne; others (1 January 2002). "A human genome diversity cell line panel". Science. 296 (5566): 261–2. doi:10.1126/science.296.5566.261b. PMID 11954565.
  • Pagani, Luca; Kivisild, Toomas; Tarekegn, Ayele; Ekong, Rosemary; Plaster, Chris; Gallego Romero, Irene; Ayub, Qasim; Mehdi, S. Qasim; Thomas, Mark G.; Luiselli, Donata; Bekele, Endashaw; Bradman, Neil; Balding, David J.; Tyler-Smith, Chris (2012). "Ethiopian Genetic Diversity Reveals Linguistic Stratification and Complex Influences on the Ethiopian Gene Pool". The American Journal of Human Genetics. 91 (1): 83–96. doi:10.1016/j.ajhg.2012.05.015. PMC 3397267. PMID 22726845.
  • Quintana-Murci, Lluís; Chaix, Raphaëlle; Wells, R. Spencer; Behar, Doron M.; Sayar, Hamid; Scozzari, Rosaria; Rengo, Chiara; Al-Zahery, Nadia; Semino, Ornella; Santachiara-Benerecetti, A. Silvana; Coppa, Alfredo; Ayub, Qasim; Mohyuddin, Aisha; Tyler-Smith, Chris; Qasim Mehdi, S.; Torroni, Antonio; McElreavey, Ken (1 May 2004). "Where West Meets East: The Complex mtDNA Landscape of the Southwest and Central Asian Corridor". The American Journal of Human Genetics. 74 (5): 827–845. doi:10.1086/383236. PMC 1181978. PMID 15077202.

References

  1. ^ "Dr Qasim Mehdi dies in Lahore". 2016-09-30.
  2. ^ a b c "Prof. S. Qasim Mehdi". hstalks.com. Retrieved 7 June 2016.
  3. ^ a b "Prof. Syed Qasem Mehdi". ias-worldwide.org. Retrieved 7 June 2016.
  4. ^ Xue, Yali; Zhang, Xuelong; Huang, Ni; Daly, Allan; Gillson, Christopher J.; MacArthur, Daniel G.; Yngvadottir, Bryndis; Nica, Alexandra C.; Woodwark, Cara; Chen, Yuan; Conrad, Donald F.; Ayub, Qasim; Mehdi, S. Qasim; Li, Pu; Tyler-Smith, Chris (1 November 2009). "Population Differentiation as an Indicator of Recent Positive Selection in Humans: An Empirical Evaluation". Genetics. 183 (3): 1065–1077. doi:10.1534/genetics.109.107722. PMC 2778960. PMID 19737746. Retrieved 7 June 2016.
  5. ^ "Syed Qasim Mehdi - Info". researchgate.net. Retrieved 7 June 2016.
  6. ^ "THE FUTURE OF MEDICINE AND BIOMEDICAL RESEARCH IN PAKISTAN: 1st Draft" (PDF). pc.gov.pk. Archived from the original (PDF) on 31 May 2016. Retrieved 7 June 2016.
  7. ^ "Syed Qasim Mehdi - Google Scholar Citations". google.com. Retrieved 7 June 2016.
  8. ^ "Distinguished scientist: Dr Qasim Mehdi passes away". 2016-09-29.
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