FREM1

FREM1
Identifiers
Aliases	FREM1, BNAR, C9orf143, C9orf145, C9orf154, MOTA, TILRR, TRIGNO2, FRAS1 related extracellular matrix 1
External IDs	OMIM: 608944; MGI: 2670972; HomoloGene: 27049; GeneCards: FREM1; OMA:FREM1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	14,910,995 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	82,970,576 bp
RNA expression pattern
	Top expressed in
	smooth muscle tissue; ; metanephros; ; body of uterus; ; right hemisphere of cerebellum; ; Descending thoracic aorta; ; ascending aorta; ; body of pancreas; ; popliteal artery; ; tibial arteries; ; right coronary artery;
	Top expressed in
	left lung lobe; ; Epithelium of choroid plexus; ; otolith organ; ; utricle; ; vas deferens; ; Gonadal ridge; ; retinal pigment epithelium; ; vestibular membrane of cochlear duct; ; ciliary body; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; carbohydrate binding;
Cellular component	integral component of membrane; extracellular region; basement membrane;
Biological process	multicellular organism development; cell communication; cell-matrix adhesion; cell adhesion; craniofacial suture morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	158326
	329872
	ENSG00000164946
	ENSMUSG00000059049
	Q5H8C1
	Q684R7
NM_001177704; NM_144966; NM_001370058; NM_001370060; NM_001370061;
	NM_001370063; NM_001370065; NM_001379081
	NM_001198811; NM_177863
NP_001171175; NP_659403; NP_001356987; NP_001356989; NP_001356990;
	NP_001356992; NP_001356994; NP_001366010
	NP_001185740; NP_808531
	Wikidata
View/Edit Human	View/Edit Mouse

FRAS1-related extracellular matrix protein 1 is a protein that in humans is encoded by the FREM1 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164946 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059049 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
^ Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ (Sep 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proc Natl Acad Sci U S A. 101 (37): 13560–5. doi:10.1073/pnas.0402760101. PMC 518794. PMID 15345741.
^ "Entrez Gene: FREM1 FRAS1 related extracellular matrix 1".

External links

GeneReviews/NCBI/NIH/UW entry on Manitoba Oculotrichoanal Syndrome, Marles Syndrome, MOTA Syndrome

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164946 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059049 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.

[pmid15345741-6] Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ (Sep 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proc Natl Acad Sci U S A. 101 (37): 13560–5. doi:10.1073/pnas.0402760101. PMC 518794. PMID 15345741.

[entrez-7] "Entrez Gene: FREM1 FRAS1 related extracellular matrix 1".

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References

Further reading

External links