AMOTL2

AMOTL2
Identifiers
Aliases	AMOTL2, LCCP, angiomotin like 2
External IDs	OMIM: 614658; MGI: 1929286; HomoloGene: 9420; GeneCards: AMOTL2; OMA:AMOTL2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q22.2 Start 134,355,347 bp End 134,375,479 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F1 Start 102,593,871 bp End 102,610,617 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid sural nerve lactiferous duct inferior ganglion of vagus nerve right coronary artery renal medulla ventricular zone germinal epithelium synovial joint parietal pleura Top expressed in calvaria adrenal gland right lung ankle ventricular zone white adipose tissue stroma of bone marrow vestibular membrane of cochlear duct lip right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding Cellular component recycling endosome cytosol endosome apical plasma membrane cytoplasmic vesicle bicellular tight junction Biological process Wnt signaling pathway hippo signaling establishment of cell polarity involved in ameboidal cell migration actin cytoskeleton organization regulation of cell migration angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51421 56332 Ensembl ENSG00000114019 ENSMUSG00000032531 UniProt Q9Y2J4 Q8K371 RefSeq (mRNA) NM_001278683 NM_001278685 NM_016201 NM_001363943 NM_019764 RefSeq (protein) NP_001265612 NP_001265614 NP_057285 NP_001350872 NP_062738 Location (UCSC) Chr 3: 134.36 – 134.38 Mb Chr 9: 102.59 – 102.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Angiomotin-like protein 2 is a protein that in humans is encoded by the AMOTL2 gene.

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.

External links

• Human AMOTL2 genome location and AMOTL2 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains". Gene. 298 (1): 69–77. doi:10.1016/S0378-1119(02)00928-9. PMID 12406577.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.