From Wikipedia, the free encyclopedia
Anthrax toxin receptor 2 (ANTXR2 also known as Capillary Morphogenesis Gene 2 or CMG2) is a protein that in humans is encoded by the ANTXR2 gene .[ 5] [ 6] [ 7]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000163297 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029338 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (Oct 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J Cell Sci . 114 (Pt 15): 2755–73. PMID 11683410 .
^ Scobie HM, Rainey GJ, Bradley KA, Young JA (Apr 2003). "Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor" . Proc Natl Acad Sci U S A . 100 (9): 5170–4. doi :10.1073/pnas.0431098100 . PMC 154317 . PMID 12700348 .
^ "Entrez Gene: ANTXR2 anthrax toxin receptor 2" .
External links
Further reading
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence" . Genome Res . 8 (11): 1097–108. doi :10.1101/gr.8.11.1097 . PMID 9847074 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Abrami L, Liu S, Cosson P, et al. (2003). "Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process" . J. Cell Biol . 160 (3): 321–8. doi :10.1083/jcb.200211018 . PMC 2172673 . PMID 12551953 .
Dowling O, Difeo A, Ramirez MC, et al. (2003). "Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis" . Am. J. Hum. Genet . 73 (4): 957–66. doi :10.1086/378781 . PMC 1180616 . PMID 12973667 .
Hanks S, Adams S, Douglas J, et al. (2003). "Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis" . Am. J. Hum. Genet . 73 (4): 791–800. doi :10.1086/378418 . PMC 1180602 . PMID 14508707 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Wigelsworth DJ, Krantz BA, Christensen KA, et al. (2004). "Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen" . J. Biol. Chem . 279 (22): 23349–56. doi :10.1074/jbc.M401292200 . PMID 15044490 .
Lacy DB, Wigelsworth DJ, Scobie HM, et al. (2004). "Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor" . Proc. Natl. Acad. Sci. U.S.A . 101 (17): 6367–72. doi :10.1073/pnas.0401506101 . PMC 404051 . PMID 15079089 .
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 . PMID 15231748 .
Santelli E, Bankston LA, Leppla SH, Liddington RC (2004). "Crystal structure of a complex between anthrax toxin and its host cell receptor". Nature . 430 (7002): 905–8. doi :10.1038/nature02763 . PMID 15243628 . S2CID 4398499 .
Lacy DB, Wigelsworth DJ, Melnyk RA, et al. (2004). "Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation" . Proc. Natl. Acad. Sci. U.S.A . 101 (36): 13147–51. doi :10.1073/pnas.0405405101 . PMC 516539 . PMID 15326297 .
Abrami L, Lindsay M, Parton RG, et al. (2004). "Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway" . J. Cell Biol . 166 (5): 645–51. doi :10.1083/jcb.200312072 . PMC 2172425 . PMID 15337774 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Lee JY, Tsai YM, Chao SC, Tu YF (2005). "Capillary morphogenesis gene-2 mutation in infantile systemic hyalinosis: ultrastructural study and mutation analysis in a Taiwanese infant". Clin. Exp. Dermatol . 30 (2): 176–9. doi :10.1111/j.1365-2230.2004.01698.x . PMID 15725249 . S2CID 45945185 .
Abrami L, Leppla SH, van der Goot FG (2006). "Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis" . J. Cell Biol . 172 (2): 309–20. doi :10.1083/jcb.200507067 . PMC 2063559 . PMID 16401723 .
Gao M, Schulten K (2007). "Onset of anthrax toxin pore formation" . Biophys. J . 90 (9): 3267–79. doi :10.1529/biophysj.105.079376 . PMC 1432108 . PMID 16473908 .
Wei W, Lu Q, Chaudry GJ, et al. (2006). "The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin" . Cell . 124 (6): 1141–54. doi :10.1016/j.cell.2005.12.045 . PMID 16564009 .
PDB gallery
1sht : Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor
1shu : Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor
1t6b : Crystal structure of B. anthracis Protective Antigen complexed with human Anthrax toxin receptor
1tzn : Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore bound to the VWA domain of CMG2, an anthrax toxin receptor