From Wikipedia, the free encyclopedia
Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene .[ 5] [ 6] [ 7]
INPP4A encodes the inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000040933 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026113 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Norris FA, Auethavekiat V, Majerus PW (Aug 1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase" . J Biol Chem . 270 (27): 16128–33. doi :10.1074/jbc.270.27.16128 PMID 7608176 . ^ Norris FA, Atkins RC, Majerus PW (Oct 1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family" . J Biol Chem . 272 (38): 23859–64. doi :10.1074/jbc.272.38.23859 PMID 9295334 . ^ a b "Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa" .
Further reading
Zhang X, Majerus PW (1998). "Phosphatidylinositol signalling reactions". Semin. Cell Dev. Biol . 9 (2): 153–60. doi :10.1006/scdb.1997.0220 . PMID 9599410 . Norris FA, Atkins RC, Majerus PW (1997). "Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets" . J. Biol. Chem . 272 (17): 10987–9. doi :10.1074/jbc.272.17.10987 PMID 9110986 . Munday AD, Norris FA, Caldwell KK, et al. (1999). "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol" . Proc. Natl. Acad. Sci. U.S.A . 96 (7): 3640–5. doi :10.1073/pnas.96.7.3640 . PMC 22347 PMID 10097090 . Joseph RE, Walker J, Norris FA (2000). "Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization". Cytogenet. Cell Genet . 87 (3–4): 276–7. doi :10.1159/000015448 . PMID 10702694 . S2CID 40002118 . Shearn CT, Walker J, Norris FA (2001). "Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene". Biochem. Biophys. Res. Commun . 286 (1): 119–25. doi :10.1006/bbrc.2001.5331 . PMID 11485317 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ivetac I, Munday AD, Kisseleva MV, et al. (2005). "The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane" . Mol. Biol. Cell . 16 (5): 2218–33. doi :10.1091/mbc.E04-09-0799 . PMC 1087230 PMID 15716355 . Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724–31. doi :10.1038/nature03466 PMID 15815621 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
