IFIT3

IFIT3
Identifiers
Aliases	IFIT3, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41, interferon induced protein with tetratricopeptide repeats 3
External IDs	OMIM: 604650; MGI: 1101055; HomoloGene: 1189; GeneCards: IFIT3; OMA:IFIT3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	89,377,473 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,566,131 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; jejunal mucosa; ; pericardium; ; lower lobe of lung; ; spinal ganglia; ; human penis; ; palpebral conjunctiva; ; monocyte; ; endothelial cell; ; synovial joint;
	Top expressed in
	right kidney; ; granulocyte; ; human kidney; ; thymus; ; jejunum; ; lung; ; colon; ; adrenal gland; ; spleen; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	identical protein binding; protein binding; molecular function; RNA binding;
Cellular component	cytoplasm; mitochondrion; cytosol;
Biological process	immune system process; response to virus; innate immune response; negative regulation of apoptotic process; defense response to virus; type I interferon signaling pathway; negative regulation of cell population proliferation; cellular response to interferon-alpha; response to bacterium; cellular response to interferon-beta;
	Sources:Amigo / QuickGO
Orthologs
	3437
	15959
	ENSG00000119917
	ENSMUSG00000074896
	O14879
	Q64345
	NM_001549; NM_001031683; NM_001289758; NM_001289759
	NM_010501
	NP_001026853; NP_001276687; NP_001276688; NP_001540
	NP_034631
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced protein with tetratricopeptide repeats 3 is a protein that in humans is encoded by the IFIT3 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119917 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074896 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ de Veer MJ, Sim H, Whisstock JC, Devenish RJ, Ralph SJ (Jan 1999). "IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes". Genomics. 54 (2): 267–77. doi:10.1006/geno.1998.5555. PMID 9828129.
^ Zhu H, Cong JP, Shenk T (Jan 1998). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs". Proc Natl Acad Sci U S A. 94 (25): 13985–90. doi:10.1073/pnas.94.25.13985. PMC 28419. PMID 9391139.
^ "Entrez Gene: IFIT3 interferon-induced protein with tetratricopeptide repeats 3".

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yu M, Tong JH, Mao M, et al. (1997). "Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7406–11. doi:10.1073/pnas.94.14.7406. PMC 23834. PMID 9207104.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119917 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074896 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9828129-5] Veer MJ, Sim H, Whisstock JC, Devenish RJ, Ralph SJ (Jan 1999). "IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes". Genomics. 54 (2): 267–77. doi:10.1006/geno.1998.5555. PMID 9828129.

[pmid9391139-6] Zhu H, Cong JP, Shenk T (Jan 1998). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs". Proc Natl Acad Sci U S A. 94 (25): 13985–90. doi:10.1073/pnas.94.25.13985. PMC 28419. PMID 9391139.

[entrez-7] "Entrez Gene: IFIT3 interferon-induced protein with tetratricopeptide repeats 3".

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References

Further reading