H2AFY2

MACROH2A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XD7
Identifiers
Aliases	MACROH2A2, macroH2A2, H2A histone family member Y2, H2AFY2, macroH2A.2 histone
External IDs	OMIM: 616141; MGI: 3037658; HomoloGene: 10246; GeneCards: MACROH2A2; OMA:MACROH2A2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	70,112,282 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	61,619,926 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; epithelium of colon; ; gingival epithelium; ; cerebellar vermis; ; pancreatic epithelial cell; ; islet of Langerhans; ; epithelium of esophagus; ; hair follicle; ; cerebellar hemisphere;
	Top expressed in
	genital tubercle; ; tail of embryo; ; neural tube; ; ventricular zone; ; maxillary prominence; ; ganglionic eminence; ; mandibular prominence; ; medial ganglionic eminence; ; otic placode; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein heterodimerization activity; chromatin DNA binding;
Cellular component	ESC/E(Z) complex; nucleoplasm; chromosome; nucleosome; chromatin; extracellular exosome; Barr body; nucleus;
Biological process	nucleosome assembly; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I; positive regulation of keratinocyte differentiation; dosage compensation; negative regulation of transcription by RNA polymerase II; establishment of protein localization to chromatin; brain development; negative regulation of gene expression, epigenetic; regulation of cell growth; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	55506
	404634
	ENSG00000099284
	ENSMUSG00000020086
	Q9P0M6
	Q8CCK0
	NM_018649
	NM_207000
	NP_061119
	NP_996883
	Wikidata
View/Edit Human	View/Edit Mouse

Core histone macro-H2A.2 is a protein that in humans is encoded by the H2AFY2 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099284 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020086 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chadwick BP, Willard HF (May 2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant". Hum Mol Genet. 10 (10): 1101–13. doi:10.1093/hmg/10.10.1101. PMID 11331621.
^ Costanzi C, Pehrson JR (Jun 2001). "MACROH2A2, a new member of the MARCOH2A core histone family". J Biol Chem. 276 (24): 21776–84. doi:10.1074/jbc.M010919200. PMID 11262398.
^ "Entrez Gene: H2AFY2 H2A histone family, member Y2".

El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang R, Poustovoitov MV, Ye X, et al. (2005). "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA". Dev. Cell. 8 (1): 19–30. doi:10.1016/j.devcel.2004.10.019. PMID 15621527.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099284 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020086 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331621-5] Chadwick BP, Willard HF (May 2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant". Hum Mol Genet. 10 (10): 1101–13. doi:10.1093/hmg/10.10.1101. PMID 11331621.

[pmid11262398-6] Costanzi C, Pehrson JR (Jun 2001). "MACROH2A2, a new member of the MARCOH2A core histone family". J Biol Chem. 276 (24): 21776–84. doi:10.1074/jbc.M010919200. PMID 11262398.

[entrez-7] "Entrez Gene: H2AFY2 H2A histone family, member Y2".

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References

Further reading