DYNC1LI1

DYNC1LI1
Identifiers
Aliases	DYNC1LI1, DNCLI1, LIC1, dynein cytoplasmic 1 light intermediate chain 1, DLC-A
External IDs	OMIM: 615890; MGI: 2135610; HomoloGene: 9403; GeneCards: DYNC1LI1; OMA:DYNC1LI1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	32,570,858 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	114,553,370 bp
RNA expression pattern
	Top expressed in
	monocyte; ; right ventricle; ; ganglionic eminence; ; gonad; ; lateral nuclear group of thalamus; ; pons; ; testicle; ; gastrocnemius muscle; ; ventricular zone; ; biceps brachii;
	Top expressed in
	neural layer of retina; ; granulocyte; ; interventricular septum; ; gastrula; ; primary visual cortex; ; right kidney; ; muscle of thigh; ; superior frontal gyrus; ; ankle; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; GDP binding; dynein heavy chain binding; GTP binding; protein binding; cytoskeletal motor activity; ATP binding; RNA binding;
Cellular component	centrosome; spindle pole; membrane; chromosome; cytoplasmic dynein complex; dynein complex; microtubule; chromosome, centromeric region; cytoskeleton; kinetochore; cytoplasm; cytosol; plasma membrane; secretory granule membrane; ficolin-1-rich granule membrane;
Biological process	positive regulation of mitotic cell cycle spindle assembly checkpoint; cell division; cell cycle; viral process; microtubule cytoskeleton organization; endoplasmic reticulum to Golgi vesicle-mediated transport; microtubule-based movement; antigen processing and presentation of exogenous peptide antigen via MHC class II; neutrophil degranulation; sister chromatid cohesion; transport;
	Sources:Amigo / QuickGO
Orthologs
	51143
	235661
	ENSG00000144635
	ENSMUSG00000032435
	Q9Y6G9
	Q8R1Q8
	NM_016141; NM_001329135
	NM_146229
	NP_001316064; NP_057225
	NP_666341
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoplasmic dynein 1 light intermediate chain 1 is a protein that in humans is encoded by the DYNC1LI1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144635 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032435 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
^ "Entrez Gene: DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Tynan SH, Purohit A, Doxsey SJ, Vallee RB (2000). "Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin". J. Biol. Chem. 275 (42): 32763–8. doi:10.1074/jbc.M001536200. PMID 10893222.
Bielli A, Thörnqvist PO, Hendrick AG, et al. (2001). "The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1". Biochem. Biophys. Res. Commun. 281 (5): 1141–53. doi:10.1006/bbrc.2001.4468. PMID 11243854.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144635 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032435 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16260502-5] Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.

[entrez-6] "Entrez Gene: DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1".

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References

Further reading