Neuronal PAS domain protein 4
Neuronal PAS domain protein 4 is a protein that in humans is encoded by the NPAS4 gene.[5] The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.[6]
Function
NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008].
Npas4 has been shown by Dr. Brenda Bloodgood to play critical roles in regulating the plasticity of inhibitory neurons. She found that Npas4 helps to regulate plasticity by orchestrating a redistribution of synaptic inputs, biasing them towards dendrites over neuronal cell bodies which increases dendritic plasticity.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000174576 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045903 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Neuronal PAS domain protein 4". Retrieved 2017-10-15.
- ^ Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa K, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019). "Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors". Cell Reports. 29 (10): 3235–3252.e9. doi:10.1016/j.celrep.2019.10.116. PMID 31801086.
- ^ Bloodgood, Brenda L.; Sharma, Nikhil; Browne, Heidi Adlman; Trepman, Alissa Z.; Greenberg, Michael E. (2013-11-07). "The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition". Nature. 503 (7474): 121–125. doi:10.1038/nature12743. ISSN 1476-4687. PMC 4169177. PMID 24201284.
Further reading
- Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression". Mol. Cell. Biol. 24 (2): 608–16. doi:10.1128/mcb.24.2.608-616.2004. PMC 343817. PMID 14701734.
- Bersten DC, Bruning JB, Peet DJ, Whitelaw ML (2014). "Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function". PLOS ONE. 9 (1): e85768. doi:10.1371/journal.pone.0085768. PMC 3894988. PMID 24465693.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Klaric TS, Thomas PQ, Dottori M, Leong WK, Koblar SA, Lewis MD (2014). "A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells". Stem Cell Res Ther. 5 (3): 64. doi:10.1186/scrt453. PMC 4076635. PMID 24887558.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa K, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019). "Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors". Cell Reports. 29 (10): 3235–3252.e9. doi:10.1016/j.celrep.2019.10.116. PMID 31801086.
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