SPINK2

SPINK2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2JXD
Identifiers
Aliases	SPINK2, HUSI-II, serine peptidase inhibitor, Kazal type 2, SPGF29, serine peptidase inhibitor Kazal type 2
External IDs	OMIM: 605753; HomoloGene: 77717; GeneCards: SPINK2; OMA:SPINK2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q12 Start 56,809,860 bp End 56,821,742 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis tail of epididymis seminal vesicula right testis left testis male germ cell sperm caput epididymis gonad testicle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity endopeptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity Cellular component extracellular region acrosomal vesicle extracellular space cytoplasmic vesicle Biological process regulation of acrosome reaction negative regulation of peptidase activity negative regulation of serine-type endopeptidase activity spermatogenesis acrosome assembly spermatid development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6691 n/a Ensembl ENSG00000128040 n/a UniProt P20155 n/a RefSeq (mRNA) NM_001271718 NM_001271719 NM_001271720 NM_001271721 NM_001271722 NM_021114 n/a RefSeq (protein) NP_001258647 NP_001258648 NP_001258649 NP_001258650 NP_001258651 NP_066937 n/a Location (UCSC) Chr 4: 56.81 – 56.82 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Serine protease inhibitor Kazal-type 2 also known as acrosin-trypsin inhibitor is a protein that in humans is encoded by the SPINK2 gene.

See also

• Kazal-type serine protease inhibitor domain

Further reading

• Wapenaar MC, Monsuur AJ, Poell J, et al. (2007). "The SPINK gene family and celiac disease susceptibility". Immunogenetics. 59 (5): 349–57. doi:10.1007/s00251-007-0199-5. PMC 1914236. PMID 17333166.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rockett JC, Patrizio P, Schmid JE, et al. (2004). "Gene expression patterns associated with infertility in humans and rodent models". Mutat. Res. 549 (1–2): 225–40. doi:10.1016/j.mrfmmm.2003.11.017. PMID 15120973.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fink E, Hehlein-Fink C, Eulitz M (1990). "Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones" (PDF). FEBS Lett. 270 (1–2): 222–4. doi:10.1016/0014-5793(90)81273-Q. PMID 2226783. S2CID 1068212.
• Collins J, Taube W, Fink E, et al. (1992). "Variants of human seminal acrosin inhibitor (HUSI-II) which inhibit human leukocyte elastase". Biomed. Biochim. Acta. 50 (4–6): 683–5. PMID 1801743.
• Möritz A, Lilja H, Fink E (1991). "Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II)". FEBS Lett. 278 (1): 127–30. doi:10.1016/0014-5793(91)80099-O. PMID 1704312. S2CID 34332531.
• Dietl T, Kruck J, Schill WB, Fritz H (1977). "Localization of seminal plasma proteinase inhibitors in human spermatozoa as revealed by the indirect immunofluorescence technique". Hoppe-Seyler's Z. Physiol. Chem. 357 (10): 1333–7. doi:10.1515/bchm2.1976.357.2.1333. PMID 791787.