Angio-associated, migratory cell protein, also known as AAMP, is a protein which in humans is encoded by the AAMPgene. This protein has been conserved in evolution and is so common to many mammals.  and it also has a yeast homolog which is the protein YCR072c.
The gene is located on the second human chromosome, near the end of the chromosome's arm (2q35), between the codons 85-87 and 1387-1389. It contains 6042 bp and 11 exons When transcribed, it gives a 1859 bp mRNA. . The vascular endothelial growth factor is a promoting factor of the protein synthesis and localisation in the different parts of the cells. The protein's expression is higher in the intracellular than in the extracellularspace.
The protein contains a WD40 domain which permits multi-proteins complexes formation  and a heparin-binding domain which mediates heparin-sensitive cell adhesion. AAMP helps to regulate vascular endothelial cell migration regulation and angiogenesis, with other signaling pathway like RhoA/Rho-kinase signaling. A malfunction can therefore lead to different diseases (see Associated diseases). For example, in the smooth muscle cells, if AAMP is overexpressed, it activates RhoA, which activates Rho-kinase (this one generates GTP) and it finally leads to increased smooth muscle cell migration and division, causing atherosclerosis and restenosis.
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