ACACB

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ACACB
PDB 2dn8 EBI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ACACB, ACC2, ACCB, HACC275, acetyl-CoA carboxylase beta
External IDs MGI: 2140940 HomoloGene: 74382 GeneCards: 32
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001093

NM_133904

RefSeq (protein)

NP_001084.3

NP_598665.2

Location (UCSC) Chr 12: 109.12 – 109.27 Mb Chr 5: 114.15 – 114.25 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an enzyme that in humans is encoded by the ACACB gene.[1][2]

Function[edit]

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine palmitoyltransferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis.[1]

Clinical implications[edit]

Human acetyl-CoA carboxylase has recently become a target in the design of new anti-obesity drugs.[3] However when the gene for ACC2 was knocked out in mice, no change in body weight was observed relative to normal mice.[4] This result suggests inhibition of ACC2 by drugs may be an ineffective method of treating obesity.

References[edit]

  1. ^ a b "Entrez Gene: acetyl-Coenzyme A carboxylase beta". 
  2. ^ Widmer J, Fassihi KS, Schlichter SC, Wheeler KS, Crute BE, King N, Nutile-McMenemy N, Noll WW, Daniel S, Ha J, Kim KH, Witters LA (June 1996). "Identification of a second human acetyl-CoA carboxylase gene". The Biochemical Journal. 316 ( Pt 3) (3): 915–22. PMC 1217437. PMID 8670171. 
  3. ^ Corbett JW, Harwood JH (November 2007). "Inhibitors of mammalian acetyl-CoA carboxylase". Recent Patents on Cardiovascular Drug Discovery 2 (3): 162–80. doi:10.2174/157489007782418928. PMID 18221116. 
  4. ^ Olson DP, Pulinilkunnil T, Cline GW, Shulman GI, Lowell BB (April 2010). "Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake". Proceedings of the National Academy of Sciences of the United States of America 107 (16): 7598–603. doi:10.1073/pnas.0913492107. PMC 2867727. PMID 20368432. 

Further reading[edit]