ACACB

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Acetyl-CoA carboxylase beta
PDB 2dn8 EBI.png
PDB rendering based on 2dn8.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACACB ; ACC2; ACCB; HACC275
External IDs OMIM601557 MGI2140940 HomoloGene74382 IUPHAR: 1264 ChEMBL: 4829 GeneCards: ACACB Gene
EC number 6.3.4.14, 6.4.1.2
Orthologs
Species Human Mouse
Entrez 32 100705
Ensembl ENSG00000076555 ENSMUSG00000042010
UniProt O00763 E9Q4Z2
RefSeq (mRNA) NM_001093 NM_133904
RefSeq (protein) NP_001084 NP_598665
Location (UCSC) Chr 12:
109.12 – 109.27 Mb
Chr 5:
114.15 – 114.25 Mb
PubMed search [1] [2]

Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an enzyme that in humans is encoded by the ACACB gene.[1][2]

Function[edit]

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine palmitoyltransferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis.[1]

Clinical implications[edit]

Human acetyl-CoA carboxylase has recently become a target in the design of new anti-obesity drugs.[3] However when the gene for ACC2 was knocked out in mice, no change in body weight was observed relative to normal mice.[4] This result suggests inhibition of ACC2 by drugs may be an ineffective method of treating obesity.

References[edit]

  1. ^ a b "Entrez Gene: acetyl-Coenzyme A carboxylase beta". 
  2. ^ Widmer J, Fassihi KS, Schlichter SC, Wheeler KS, Crute BE, King N, Nutile-McMenemy N, Noll WW, Daniel S, Ha J, Kim KH, Witters LA (June 1996). "Identification of a second human acetyl-CoA carboxylase gene". Biochem. J. 316 (3): 915–22. PMC 1217437. PMID 8670171. 
  3. ^ Corbett JW, Harwood JH (November 2007). "Inhibitors of mammalian acetyl-CoA carboxylase". Recent Patents Cardiovasc Drug Discov 2 (3): 162–80. doi:10.2174/157489007782418928. PMID 18221116. 
  4. ^ Olson DP, Pulinilkunnil T, Cline GW, Shulman GI, Lowell BB (April 2010). "Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake". Proc Natl Acad Sci U S A 107 (16): 7598–7603. doi:10.1073/pnas.0913492107. PMC 2867727. PMID 20368432. 

Further reading[edit]