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Aliases ACSL6, ACS2, FACL6, LACS 6, LACS2, LACS5, acyl-CoA synthetase long-chain family member 6, acyl-CoA synthetase long chain family member 6
External IDs OMIM: 604443 MGI: 894291 HomoloGene: 100939 GeneCards: ACSL6
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for ACSL6
Genomic location for ACSL6
Band No data available Start 131,949,973 bp[1]
End 132,012,243 bp[1]
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 5: 131.95 – 132.01 Mb Chr 5: 54.3 – 54.36 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene.[5][6][7] Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA.[6]


The ACSL6 gene is located on the 5th chromosome, with its specific location being 5q31.1. The gene contains 23 exons.[5] ACSL6 encodes a 77.7 kDa protein that is composed of 697 amino acids; 10 peptides have been observed through mass spectrometry data.[8][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164398 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020333 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: acyl-CoA synthetase long-chain family member 6". 
  6. ^ a b Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (November 1999). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors". Biochem. J. 344 Pt 1 (Pt 1): 135–43. PMC 1220623Freely accessible. PMID 10548543. doi:10.1042/0264-6021:3440135. 
  7. ^ Yagasaki F, Jinnai I, Yoshida S, Yokoyama Y, Matsuda A, Kusumoto S, Kobayashi H, Terasaki H, Ohyashiki K, Asou N, Murohashi I, Bessho M, Hirashima K (November 1999). "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)". Genes Chromosomes Cancer. 26 (3): 192–202. PMID 10502316. doi:10.1002/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E. 
  8. ^ ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. PMC 4076475Freely accessible. PMID 23965338. doi:10.1161/CIRCRESAHA.113.301151. 
  9. ^ "Long-chain-fatty-acid--CoA ligase 6". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). 

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