ACTL6B

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ACTL6B
Identifiers
Aliases ACTL6B, ACTL6, BAF53B, arpNalpha, actin like 6B
External IDs MGI: 1933548 HomoloGene: 81844 GeneCards: ACTL6B
RNA expression pattern
PBB GE ACTL6B 206013 s at fs.png

PBB GE ACTL6B 206014 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016188

NM_031404

RefSeq (protein)

NP_057272

NP_113581.1
NP_113581

Location (UCSC) Chr 7: 100.64 – 100.66 Mb Chr 5: 137.55 – 137.57 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.[3][4]

Function[edit]

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.[4]

Interactions[edit]

ACTL6B has been shown to interact with CTBP1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (December 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788Freely accessible. PMID 9799793. 
  4. ^ a b "Entrez Gene: ACTL6B actin-like 6B". 
  5. ^ Oma Y, Nishimori K, Harata M (February 2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893. 

External links[edit]

Further reading[edit]