ADD1

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ADD1
Identifiers
Aliases ADD1, ADDA, adducin 1
External IDs MGI: 87918 HomoloGene: 22758 GeneCards: 118
RNA expression pattern
PBB GE ADD1 208030 s at tn.png

PBB GE ADD1 214726 x at tn.png

PBB GE ADD1 214736 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001119
NM_001286645
NM_014189
NM_014190
NM_176801

NM_001024458
NM_001102444
NM_013457

RefSeq (protein)

NP_001110.2
NP_001273574.1
NP_054908.2
NP_054909.2
NP_789771.1

NP_001019629.2
NP_001095914.1
NP_038485.1

Location (UCSC) Chr 4: 2.84 – 2.93 Mb Chr 5: 34.57 – 34.63 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.[3][4]

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Polymorphism in ADD1 is associated with hypertension.[4]

References[edit]

Further reading[edit]