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AliasesADD1, ADDA, adducin 1
External IDsMGI: 87918 HomoloGene: 22758 GeneCards: ADD1
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ADD1
Genomic location for ADD1
Band4p16.3Start2,843,857 bp[1]
End2,930,076 bp[1]
RNA expression pattern
PBB GE ADD1 214736 s at fs.png

PBB GE ADD1 214726 x at fs.png

PBB GE ADD1 208030 s at fs.png
More reference expression data
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 4: 2.84 – 2.93 MbChr 5: 34.57 – 34.63 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.[5][6]

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Polymorphism in ADD1 is associated with hypertension.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087274 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029106 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Joshi R, Gilligan DM, Otto E, McLaughlin T, Bennett V (Nov 1991). "Primary structure and domain organization of human alpha and beta adducin". J Cell Biol. 115 (3): 665–75. doi:10.1083/jcb.115.3.665. PMC 2289184. PMID 1840603.
  6. ^ a b "Entrez Gene: ADD1 adducin 1 (alpha)".

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