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Adducin 1 (alpha)
Symbols ADD1 ; ADDA
External IDs OMIM102680 MGI87918 HomoloGene22758 GeneCards: ADD1 Gene
RNA expression pattern
PBB GE ADD1 208030 s at tn.png
PBB GE ADD1 214726 x at tn.png
PBB GE ADD1 214736 s at tn.png
More reference expression data
Species Human Mouse
Entrez 118 11518
Ensembl ENSG00000087274 ENSMUSG00000029106
UniProt P35611 Q9QYC0
RefSeq (mRNA) NM_001119 NM_001024458
RefSeq (protein) NP_001110 NP_001019629
Location (UCSC) Chr 4:
2.84 – 2.93 Mb
Chr 5:
34.57 – 34.63 Mb
PubMed search [1] [2]

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.[1][2]

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Polymorphism in ADD1 is associated with hypertension.[2]


  1. ^ Joshi R, Gilligan DM, Otto E, McLaughlin T, Bennett V (Nov 1991). "Primary structure and domain organization of human alpha and beta adducin". J Cell Biol 115 (3): 665–75. doi:10.1083/jcb.115.3.665. PMC 2289184. PMID 1840603. 
  2. ^ a b "Entrez Gene: ADD1 adducin 1 (alpha)". 

Further reading[edit]