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AFF3

From Wikipedia, the free encyclopedia
AFF3
Identifiers
AliasesAFF3, LAF4, MLLT2-like, AF4/FMR2 family member 3, KINS
External IDsOMIM: 601464; MGI: 106927; HomoloGene: 1718; GeneCards: AFF3; OMA:AFF3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001025108
NM_002285
NM_001386135

NM_001290814
NM_010678

RefSeq (protein)

NP_001020279
NP_002276

NP_001277743

Location (UCSC)Chr 2: 99.55 – 100.19 MbChr 1: 38.22 – 38.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AF4/FMR2 family member 3 is a protein that in humans is encoded by the AFF3 gene.[5][6][7]

Function

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This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved AF4/FMR2 family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144218Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037138Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liao X, Ma C, Trask B, Massa H, Gilbert DJ, Staudt LM, Jenkins NA, Copeland NG (Jun 1996). "LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12". Mammalian Genome. 7 (6): 467–8. doi:10.1007/s003359900137. PMID 8662235. S2CID 1525532.
  6. ^ Ma C, Staudt LM (Jan 1996). "LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias". Blood. 87 (2): 734–45. doi:10.1182/blood.V87.2.734.bloodjournal872734. PMID 8555498.
  7. ^ a b "Entrez Gene: AFF3 AF4/FMR2 family, member 3".
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Further reading

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