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Aliases AFF3, LAF4, MLLT2-like, AF4/FMR2 family member 3
External IDs MGI: 106927 HomoloGene: 1718 GeneCards: AFF3
RNA expression pattern
PBB GE AFF3 205735 s at fs.png

PBB GE AFF3 205734 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 99.55 – 100.14 Mb Chr 1: 38.18 – 38.66 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

AF4/FMR2 family member 3 is a protein that in humans is encoded by the AFF3 gene.[3][4][5]


This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Liao X, Ma C, Trask B, Massa H, Gilbert DJ, Staudt LM, Jenkins NA, Copeland NG (Jun 1996). "LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12". Mammalian Genome. 7 (6): 467–8. doi:10.1007/s003359900137. PMID 8662235. 
  4. ^ Ma C, Staudt LM (Jan 1996). "LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias". Blood. 87 (2): 734–45. PMID 8555498. 
  5. ^ a b "Entrez Gene: AFF3 AF4/FMR2 family, member 3". 

External links[edit]

Further reading[edit]

  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • von Bergh AR, Beverloo HB, Rombout P, van Wering ER, van Weel MH, Beverstock GC, Kluin PM, Slater RM, Schuuring E (Sep 2002). "LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia". Genes, Chromosomes & Cancer. 35 (1): 92–6. doi:10.1002/gcc.10091. PMID 12203795. 
  • Hiwatari M, Taki T, Taketani T, Taniwaki M, Sugita K, Okuya M, Eguchi M, Ida K, Hayashi Y (May 2003). "Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)". Oncogene. 22 (18): 2851–5. doi:10.1038/sj.onc.1206389. PMID 12743608. 
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • To MD, Faseruk SA, Gokgoz N, Pinnaduwage D, Done SJ, Andrulis IL (Jul 2005). "LAF-4 is aberrantly expressed in human breast cancer". International Journal of Cancer. Journal International Du Cancer. 115 (4): 568–74. doi:10.1002/ijc.20881. PMID 15704140.