ANAPC5

ANAPC5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC5, APC5, anaphase promoting complex subunit 5
External IDs	OMIM: 606948; MGI: 1929722; HomoloGene: 41118; GeneCards: ANAPC5; OMA:ANAPC5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	121,399,896 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	122,959,402 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; body of pancreas; ; bronchial epithelial cell; ; tibia; ; canal of the cervix; ; skin of hip; ; body of uterus; ; corpus callosum; ; tibial nerve; ; right ovary;
	Top expressed in
	fossa; ; condyle; ; internal carotid artery; ; external carotid artery; ; fetal liver hematopoietic progenitor cell; ; Paneth cell; ; superior cervical ganglion; ; hair follicle; ; trigeminal ganglion; ; vas deferens;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase binding; ubiquitin protein ligase activity;
Cellular component	nucleoplasm; cytosol; nucleus; anaphase-promoting complex;
Biological process	cell cycle; anaphase-promoting complex-dependent catabolic process; protein ubiquitination; protein K11-linked ubiquitination; cell division; positive regulation of mitotic metaphase/anaphase transition; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	51433
	59008
	ENSG00000089053
	ENSMUSG00000029472
	Q9UJX4
	Q8BTZ4
	NM_001137559; NM_016237; NM_001330489
NM_001042491; NM_001289517; NM_001289518; NM_001289519; NM_001289520;
	NM_021505
	NP_001131031; NP_001317418; NP_057321
NP_001035956; NP_001276446; NP_001276447; NP_001276448; NP_001276449;
	NP_067480
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.^[5]^[6]

Template:PBB Summary

Interactions

ANAPC5 has been shown to interact with ANAPC1,^[7]^[8] ANAPC4,^[7] CDC27^[7]^[9]^[10] and PABPC1.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089053 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029472 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. doi:10.1126/science.279.5354.1219. PMID 9469815.
^ "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5".
^ ^a ^b ^c Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17). England: 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J. Cell Biol. 151 (4). UNITED STATES: 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ ^a ^b Koloteva-Levine, Nadejda; Pinchasi, Dalia; Pereman, Idan; Zur, Amit; Brandeis, Michael; Elroy-Stein, Orna (May 2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. 24 (9). United States: 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. ISSN 0270-7306. PMC 387753. PMID 15082755. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16). UNITED STATES: 8973–8. doi:10.1073/pnas.97.16.8973. ISSN 0027-8424. PMC 16806. PMID 10922056. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading