ANTXR1

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ANTXR1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ANTXR1, ATR, GAPO, TEM8, anthrax toxin receptor 1
External IDs MGI: 1916788 HomoloGene: 12976 GeneCards: 84168
RNA expression pattern
PBB GE ANTXR1 220092 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018153
NM_032208
NM_053034

NM_054041

RefSeq (protein)

NP_060623.2
NP_115584.1
NP_444262.1
NP_060623.2

NP_473382.1

Location (UCSC) Chr 2: 69.01 – 69.25 Mb Chr 6: 87.13 – 87.34 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Anthrax toxin receptor 1 is a protein that in humans is encoded by the ANTXR1 gene.[1][2][3]

The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.[3]

See also[edit]

References[edit]

  1. ^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988. 
  2. ^ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (Sep 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res 61 (18): 6649–55. PMID 11559528. 
  3. ^ a b "Entrez Gene: ANTXR1 anthrax toxin receptor 1". 

Further reading[edit]