ANTXR1

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ANTXR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANTXR1, ATR, GAPO, TEM8, anthrax toxin receptor 1, ANTXR cell adhesion molecule 1
External IDsMGI: 1916788 HomoloGene: 12976 GeneCards: ANTXR1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ANTXR1
Genomic location for ANTXR1
Band2p13.3Start69,013,178 bp[1]
End69,249,327 bp[1]
RNA expression pattern
PBB GE ANTXR1 220092 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018153
NM_032208
NM_053034

NM_054041

RefSeq (protein)

NP_060623
NP_115584
NP_444262
NP_060623.2

NP_473382

Location (UCSC)Chr 2: 69.01 – 69.25 MbChr 6: 87.13 – 87.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Anthrax toxin receptor 1 (ANTXR1 or also known asTEM8) is a protein that in humans is encoded by the ANTXR1 gene.[5][6][7] Its molecular weight is predicted as about 63kDa.

The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169604 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033420 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988. 
  6. ^ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (Sep 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res. 61 (18): 6649–55. PMID 11559528. 
  7. ^ a b "Entrez Gene: ANTXR1 anthrax toxin receptor 1". 

External links[edit]

Further reading[edit]