ARHGEF10

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ARHGEF10
Identifiers
AliasesARHGEF10, GEF10, SNCV, Rho guanine nucleotide exchange factor 10
External IDsOMIM: 608136 MGI: 2444453 HomoloGene: 22827 GeneCards: ARHGEF10
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ARHGEF10
Genomic location for ARHGEF10
Band8p23.3Start1,823,926 bp[1]
End1,958,641 bp[1]
RNA expression pattern
PBB GE ARHGEF10 215139 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308152
NM_001308153
NM_014629

NM_001037736
NM_172751

RefSeq (protein)

NP_001295081
NP_001295082
NP_055444

NP_001032825
NP_766339

Location (UCSC)Chr 8: 1.82 – 1.96 MbChr 8: 14.91 – 15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.[5][6][7]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.[7]

References[edit]

  1. ^ a b c ENSG00000274726 GRCh38: Ensembl release 89: ENSG00000104728, ENSG00000274726 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071176 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  6. ^ Mohl M, Winkler S, Wieland T, Lutz S (Aug 2006). "Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture". Naunyn Schmiedebergs Arch Pharmacol. 373 (5): 333–41. doi:10.1007/s00210-006-0083-0. PMID 16896804.
  7. ^ a b "Entrez Gene: ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10".

External links[edit]

Further reading[edit]