Jump to content

ARHGEF12

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Monkbot (talk | contribs) at 00:24, 29 April 2015 (→‎Further reading: Task 7: replace et al. in author/editor parameters with |display-authors=etal or |display-editors=etal;). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Template:PBB Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.[1][2][3]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptor . The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.[3]

Clinical significance

This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.[3]

Interactions

ARHGEF12 has been shown to interact with:

References

  1. ^ Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA (April 2000). "Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia". Proc Natl Acad Sci U S A. 97 (5): 2145–50. doi:10.1073/pnas.040569197. PMC 15768. PMID 10681437.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ a b c "Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12".
  4. ^ a b Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ a b c d Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ Taya S, Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K (November 2001). "Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF". J. Cell Biol. 155 (5): 809–20. doi:10.1083/jcb.200106139. PMC 2150867. PMID 11724822.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ^ Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (September 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ (July 2001). "Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA". J. Biol. Chem. 276 (29): 27145–51. doi:10.1074/jbc.M103565200. PMID 11373293.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

Further reading

Stub icon

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=ARHGEF12&oldid=659776332"