ARHGEF5

ARHGEF5
Identifiers
Aliases	ARHGEF5, GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5
External IDs	OMIM: 600888; MGI: 1858952; HomoloGene: 66300; GeneCards: ARHGEF5; OMA:ARHGEF5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	144,380,632 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	43,266,254 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; duodenum; ; minor salivary glands; ; kidney; ; body of pancreas; ; prostate; ; vagina; ; islet of Langerhans;
	Top expressed in
	epithelium of stomach; ; duodenum; ; lip; ; jejunum; ; large intestine; ; colon; ; pyloric antrum; ; mucous cell of stomach; ; left colon; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP binding; protein binding; lipid binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cell projection; plasma membrane; nucleoplasm; cell junction; podosome; nucleus; cell periphery; cytosol;
Biological process	intracellular signal transduction; regulation of actin cytoskeleton organization; positive regulation of JUN kinase activity; regulation of GTPase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of podosome assembly; myeloid dendritic cell chemotaxis; positive regulation of GTPase activity; positive regulation of protein import; regulation of ERK1 and ERK2 cascade; regulation of Rho protein signal transduction; regulation of cytoskeleton organization; actin cytoskeleton organization; positive regulation of stress fiber assembly; positive regulation of apoptotic process; regulation of small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7984
	54324
	ENSG00000050327
	ENSMUSG00000033542
	Q12774
	E9Q7D5
	NM_001002861; NM_005435
	NM_133674
	NP_005426
	NP_598435
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000050327 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033542 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T (Apr 1994). "Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins". Oncogene. 9 (4): 1057–63. PMID 8134109.
^ Takai S, Chan AM, Yamada K, Miki T (Oct 1995). "Assignment of the human TIM proto-oncogene to 7q33→q35". Cancer Genet Cytogenet. 83 (1): 87–9. doi:10.1016/S0165-4608(95)00017-8. PMID 7656213.
^ "Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5".

References

Further reading